Layer- and area-specific actions of norepinephrine on cortical synaptic transmission

Brain Research
Humberto SalgadoMarco Atzori

Abstract

The cerebral cortex is a critical target of the central noradrenergic system. The importance of norepinephrine (NE) in the regulation of cortical activity is underscored by clinical findings that involve this catecholamine and its receptor subtypes in the regulation of a large number of emotional and cognitive functions and illnesses. In this review, we highlight diverse effects of the LC/NE system in the mammalian cortex. Indeed, electrophysiological, pharmacological, and behavioral studies in the last few decades reveal that NE elicits a mixed repertoire of excitatory, inhibitory, and biphasic effects on the firing activity and transmitter release of cortical neurons. At the intrinsic cellular level, NE can produce a series of effects similar to those elicited by other monoamines or acetylcholine, associated with systemic arousal. At the synaptic level, NE induces numerous acute changes in synaptic function, and ׳gates' the induction of long-term plasticity of glutamatergic synapses, consisting in an enhancement of engaged and relevant cortical synapses and/or depression of unengaged synapses. Equally important in shaping cortical function, in many cortical areas NE promotes a characteristic, most often reversible, increase i...Continue Reading

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Citations

Jun 9, 2016·Frontiers in Synaptic Neuroscience·Mario Treviño
Sep 13, 2016·Frontiers in Synaptic Neuroscience·Marco AtzoriHumberto Salgado
Jun 5, 2019·The European Journal of Neuroscience·Horst SchicknickWolfgang Tischmeyer
Jun 22, 2019·Central Nervous System Agents in Medicinal Chemistry·Saganuwan Alhaji Saganuwan
Jun 3, 2020·PLoS Computational Biology·Florent Meyniel
Aug 11, 2020·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Mara Mather
Jul 17, 2018·Neural Plasticity·Olga BorodovitsynaDaniel Chandler
Oct 13, 2017·Journal of Neurophysiology·Vanessa LeeLuke Remage-Healey
Jun 27, 2018·Nature Communications·Iain StittFlavio Fröhlich
Mar 30, 2018·Frontiers in Neural Circuits·Rylan S Larsen, Jack Waters
Apr 6, 2019·Frontiers in Synaptic Neuroscience·Mario TreviñoElí Lezama
Oct 28, 2019·Frontiers in Human Neuroscience·R L van den BrinkT H Donner
Apr 10, 2019·PLoS Computational Biology·Micha Heilbron, Florent Meyniel
Nov 3, 2020·Frontiers in Systems Neuroscience·Andrea MatteraGianluca Baldassarre
Aug 21, 2020·Physiological Reviews·Jochen F Staiger, Carl C H Petersen
Nov 17, 2020·Frontiers in Cellular Neuroscience·Anthony G PacholkoLane K Bekar
Mar 16, 2021·Frontiers in Cellular Neuroscience·Jérôme Wahis, Matthew G Holt
Apr 12, 2021·NeuroImage. Clinical·Alexander MünchauChristian Beste
Jun 12, 2021·Frontiers in Neural Circuits·Gabrielle EwallHey-Kyoung Lee
Sep 22, 2021·Psychopharmacology·Keisuke TsunodaSatoshi Shimegi

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