Layer 5 Corticofugal Projections from Diverse Cortical Areas: Variations on a Pattern of Thalamic and Extrathalamic Targets.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Judy A PrasadS Murray Sherman

Abstract

The cerebral cortex, with all its computational power, can only influence behavior via corticofugal connections originating from layer 5 (L5) cells (Sherman and Guillery, 2013). To begin to establish the global pattern of these outputs, we examined L5 efferents originating from four cortical areas: somatosensory, visual, motor, and prefrontal (i.e., ventromedial orbitofrontal) cortex. We injected Cre-dependent adeno-associated virus in an Rbp4-Cre transgenic mouse line (both sexes) to label these L5 efferents selectively. Our study reveals that, across this diverse series of cortical regions, L5 commonly projects to multiple thalamic and extrathalamic sites. We also identified several novel corticofugal targets (i.e., the lateral dorsal nucleus, submedial nucleus) previously unidentified as L5 targets. We identified common patterns for these projections: all areas innervated both thalamus and the midbrain, and all areas innervated multiple thalamic targets, including those with core and matrix cell types (Jones, 1998). An examination of the terminal size within each of these targets suggests that terminal populations of L5 efferents are not consistently large but vary with cortical area and target; and in some cases, these incl...Continue Reading

Citations

Feb 9, 2021·Frontiers in Neural Circuits·Alexander Asilador, Daniel A Llano
Mar 17, 2021·The Journal of Comparative Neurology·Nidhi Vasant Desai, Carmen Varela
May 4, 2021·Frontiers in Behavioral Neuroscience·Kara K Cover, Brian N Mathur
Jul 24, 2021·Neuron·S Murray Sherman, W Martin Usrey
Jul 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Vandana SampathkumarNarayanan Kasthuri
Aug 4, 2021·Nature Neuroscience·Lukas B KroneVladyslav V Vyazovskiy
Sep 30, 2021·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·John R Economides, Jonathan C Horton

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