Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability

Langmuir : the ACS Journal of Surfaces and Colloids
Eliana MazaOmar Azzaroni

Abstract

Responsive interfacial architectures of practical interest commonly require the combination of conflicting properties in terms of their demand upon material structure. Switchable stiffness, wettability, and permeability, key features for tissue engineering applications, are in fact known to be exclusively interdependent. Here, we present a nanoarchitectonic approach that decouples these divergent properties by the use of thermoresponsive microgels as building blocks for the construction of three-dimensional arrays of interconnected pores. Layer-by-layer assembled poly( N-isopropylacrylamide- co-methacrylic acid) microgel films were found to exhibit an increase in hydrophobicity, stiffness, and adhesion properties upon switching the temperature from below to above the lower critical solution temperature, whereas the permeability of redox probes through the film remained unchanged. Our findings indicate that the switch in hydrophilicity and nanomechanical properties undergone by the microgels does not compromise the porosity of the film, thus allowing the free diffusion of redox probes through the polymer-free volume of the submicrometer pores. This novel approach for decoupling conflicting properties provides a strategic route f...Continue Reading

References

Sep 14, 2004·Biomacromolecules·Christine M NolanL Andrew Lyon
May 18, 2005·Journal of Colloid and Interface Science·Eun Chul ChoKilwon Cho
Mar 10, 2006·Annals of Biomedical Engineering·Nathan J SniadeckiChristopher S Chen
May 17, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Verawan NerapusriIbraheem A Bushnak
Dec 28, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·M C LeMieuxV V Tsukruk
Oct 14, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Stephan SchmidtRegine von Klitzing
Mar 30, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ali M LehafJoseph B Schlenoff
Jul 23, 2011·Nature Chemistry·Morgan D MagerMolly M Stevens
Jan 10, 2012·Advanced Materials·Masakazu AonoKatsuhiko Ariga
Jul 28, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Chunhong YeVladimir V Tsukruk
Sep 24, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Kimberly C Clarke, L Andrew Lyon
Jun 14, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Ling ZhangL Andrew Lyon
Feb 6, 2016·Advanced Materials·Katsuhiko Ariga, Junbai Li
Apr 24, 2007·Soft Matter·Paul A FitzGeraldErica J Wanless

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