Layer-by-layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility assessment

Journal of Biomedical Materials Research. Part a
Yanwei TangTong Lin

Abstract

Bonded fibrous matrices have shown great potential in tissue engineering because of their unique 3D structures and pore characteristics. For some applications, bacterial infections must be taken into account, and antibacterial function is highly desired. In this study, an antibacterial polymer, polyhexamethylene biguanide (PHMB), was applied onto the fiber surface of a bonded poly(ε-caprolactone) (PCL) fibrous matrix with the objective to achieve both strong antibacterial effect and good cell compatibility. The coatings were prepared by using an electrostatic layer-by-layer (LbL) assembly technique, which allowed the control of PHMB loading and coating uniformity on the fiber surface. The PHMB coating provided antibacterial activities, but had no toxicity on mammalian cells. This bonded PCL fibrous matrix with electrostatically self-assembled PHMB may provide a new antiinfective tissue scaffold for various biomedical applications.

References

May 14, 1993·Science·R Langer, J P Vacanti
Jul 1, 1997·Journal of Biomedical Materials Research·M LampinM F Sigot-Luizard
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R O Darouiche
Feb 9, 2002·Journal of Biomedical Materials Research·Kornelis A PoelstraDavid W Grainger
Feb 18, 2003·JAMA : the Journal of the American Medical Association·Melinda M NeuhauserJohn P Quinn
Jun 4, 2005·The Laryngoscope·Christopher Y ChangGregory F Hulka
Sep 13, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fred C KrebsBrian Wigdahl
Aug 29, 2006·Chemical Society Reviews·Evan M Hetrick, Mark H Schoenfisch
Jun 29, 2007·Biomaterials·Roel KuijerHenk J Busscher
Nov 21, 2007·Toxicology Letters·X Chen, H J Schluesener
Mar 28, 2008·The Journal of Antimicrobial Chemotherapy·Gerald Müller, Axel Kramer
Jun 12, 2008·Implant Dentistry·Devorah Schwartz-AradLiran Levin
Oct 16, 2008·Journal of Biomaterials Science. Polymer Edition·J V AraujoN M Neves
Mar 31, 2009·The Journal of Hospital Infection·A D PyeA J Smith
Sep 8, 2009·Environmental Science & Technology·Koji KawataSatoshi Okabe
Sep 23, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Cornelia WiegandUta-Christina Hipler

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Citations

Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Shanshan GuoXian Jun Loh
Feb 9, 2013·Biomaterials·Stuart B GoodmanFan Yang
Feb 6, 2017·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Kostantinos MalizosCarlo Luca Romanò
Jun 21, 2017·Biofabrication·Yongliang ZhangChengtie Wu
May 23, 2017·Journal of Bone and Joint Infection·Carlo Luca RomanòLorenzo Drago
Sep 5, 2018·Journal of Orthopaedic Surgery and Research·Chenhao PanXiaowei Yu
Aug 1, 2015·Sports Medicine and Arthroscopy Review·Knut BeitzelAugustus D Mazzocca
Oct 3, 2015·Journal of Orthopaedic Surgery and Research·Carlo Luca RomanòLorenzo Drago
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Matteo ZanoccoGiuseppe Pezzotti
Aug 13, 2018·ACS Biomaterials Science & Engineering·Jun ZhangXin Liu

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