Layer Specific Development of Neocortical Pyramidal to Fast Spiking Cell Synapses

Frontiers in Cellular Neuroscience
Olga VoinovaA Rozov

Abstract

All cortical neurons are engaged in inhibitory feedback loops which ensure excitation-inhibition balance and are key elements for the development of coherent network activity. The resulting network patterns are strongly dependent on the strength and dynamic properties of these excitatory-inhibitory loops which show pronounced regional and developmental diversity. Therefore we compared the properties and postnatal maturation of two different synapses between rat neocortical pyramidal cells (layer 2/3 and layer 5, respectively) and fast spiking (FS) interneurons in the corresponding layer. At P14, both synapses showed synaptic depression upon repetitive activation. Synaptic release properties between layer 2/3 pyramidal cells and FS cells were stable from P14 to P28. In contrast, layer 5 pyramidal to FS cell connections showed a significant increase in paired pulse ratio by P28. Presynaptic calcium dynamics also changed at these synapses, including sensitivity to exogenously loaded calcium buffers and expression of presynaptic calcium channel subtypes. These results underline the large variety of properties at different, yet similar, synapses in the neocortex. They also suggest that postnatal maturation of the brain goes along wi...Continue Reading

References

Sep 1, 1989·Brain Research. Developmental Brain Research·D MullerG Lynch
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Choi, D M Lovinger
Apr 9, 1999·Nature Neuroscience·A ReyesB Sakmann
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Jun 18, 2002·Science·Xavier LeinekugelGyörgy Buzsáki
Sep 3, 2002·Journal of Neurophysiology·Hannele LahtinenTomi Taira
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bidisha ChattopadhyayaZ Josh Huang
Mar 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark O CunninghamClaudia Racca
Nov 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Steven MiddletonMark O Cunningham
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel DoischerMarlene Bartos
Apr 28, 2009·Nature·Jessica A CardinChristopher I Moore
Apr 28, 2009·Nature·Vikaas S SohalKarl Deisseroth
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin W OkatySacha B Nelson
Sep 26, 2009·Neuron·Paul Tiesinga, Terrence J Sejnowski
Aug 11, 2010·Neuron·Matthew T ColonneseRustem Khazipov
Dec 15, 2010·Developmental Neurobiology·Miles A WhittingtonRoger D Traub
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth A BuffaloRobert Desimone
Oct 15, 2011·Science·Marat MinlebaevRoustem Khazipov
Mar 27, 2012·Annual Review of Neuroscience·György Buzsáki, Xiao-Jing Wang
Jul 23, 2013·Neuroscience·R KhazipovG Valeeva
Mar 4, 2015·ELife·Jonas-Frederic SauerMarlene Bartos

❮ Previous
Next ❯

Citations

Oct 27, 2018·Frontiers in Cellular Neuroscience·Andrei RozovFliza Valiullina-Rakhmatullina
Apr 2, 2019·Frontiers in Cellular Neuroscience·Alexey P BolshakovAndrei Rozov

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence microscopy
infrared microscopy

Software Mentioned

SigmaPlot
Igor Pro
PULSE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.