Layered double hydroxides as effective carrier for anticancer drugs and tailoring of release rate through interlayer anions.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Sudipta SenapatiPralay Maiti

Abstract

Hydrophobic anticancer drug, raloxifene hydrochloride (RH) is intercalated into a series of magnesium aluminum layered double hydroxides (LDHs) with various charge density anions through ion exchange technique for controlled drug delivery. The particle nature of the LDH in presence of drug is determined through electron microscopy and surface morphology. The release of drug from the RH intercalated LDHs was made very fast or sustained by altering the exchangeable anions followed by the modified Freundlich and parabolic diffusion models. The drug release rate is explained from the interactions between the drug and LDHs along with order-disorder structure of drug intercalated LDHs. Nitrate bound LDH exhibits greater interaction with drug and sustained drug delivery against the loosely interacted phosphate bound LDH-drug, which shows fast release. Cell viability through MTT assay suggests drug intercalated LDHs as better drug delivery vehicle for cancer cell line against poor bioavailability of the pure drug. In vivo study with mice indicates the differential tumor healing which becomes fast for greater drug release system but the body weight index clearly hints at damaged organ in the case of fast release system. Histopathologica...Continue Reading

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Citations

Apr 26, 2016·International Journal of Pharmaceutics·Mohamed Amine DjebbiAbdesslem Ben Haj Amara
Jun 19, 2017·International Journal of Biological Macromolecules·Sunil KumarPralay Maiti
Jul 10, 2018·Expert Opinion on Drug Delivery·Yanyan WangFeng Cao
Apr 17, 2019·Journal of Biomedical Materials Research. Part a·Sudipta SenapatiPralay Maiti
Oct 23, 2019·Signal Transduction and Targeted Therapy·Akhand Pratap SinghPralay Maiti
Aug 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alok RaiPralay Maiti
Mar 1, 2019·International Journal of Molecular Sciences·Safia NazJinghua Chen
Jul 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Arup PodderSankarprasad Bhuniya
Mar 22, 2018·Signal Transduction and Targeted Therapy·Sudipta SenapatiPralay Maiti
Aug 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinyu LiWeisan Pan
Aug 30, 2020·Signal Transduction and Targeted Therapy·Akhand Pratap SinghPralay Maiti
Jul 5, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·André Luiz Moreira Domingues de SousaPedro José Rolim Neto
May 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Arpan BiswasPralay Maiti
Nov 23, 2017·ACS Applied Materials & Interfaces·Seon Sook LeeByeongmoon Jeong
Aug 27, 2021·The Journal of Physical Chemistry. B·Sudipta SenapatiPralay Maiti
Sep 10, 2019·Bioconjugate Chemistry·Sudipta SenapatiPralay Maiti
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sheikh Ahmad Izaddin Sheikh Mohd GhazaliFarah Liyana Bohari

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