PMID: 12774954May 31, 2003Paper

Lazaroid attenuates edema by stabilizing ATPase in the traumatized rat brain

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
R DurmazEsref Tel

Abstract

The aim of the present study was to determine the potential therapeutic value of the lazaroid U-83836E on blood brain barrier (BBB) breakdown and edema with respect to the changes in the synaptosomal Na+/K+ and Mg(2+)/Ca(2+)-adenosinetriphosphatase (ATPase) activities, tissue malondialdehyde levels and the neuronal viability in the rat brain subjected to cerebral trauma. Traumatic brain injury (TBI) was introduced by applying a 75 gm. cm force to the right parietal cortex using the weight-drop method. The first set of animals was used for determining time course changes of the synaptosomal Na+/K+ and Mg(2+)/Ca(2+)-ATPase and the malondialdehyde levels and were sacrificed 2, 6 and 24h after lesion production. A group of the animals was treated with U-83836E proir to TBI and sacrificed 24h after cerebral injury. A second set of animals was used for evaluating the alterations in BBB disruption and tissue water content and were sacrificed 2, 6 and 24h after lesion production. Two groups of animals were treated with U-83836E and sacrificed after 2 and 24h following TBI. U-83836E was given intraperitoneally thirty minutes before trauma at a dose of 10 mg/kg. Neuronal necrosis was also evaluated in the groups of U-83836E and physiolog...Continue Reading

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Citations

Jul 15, 2015·Neurochemical Research·Pooja Khanna SoodBimla Nehru
Sep 3, 2016·Proteomics. Clinical Applications·D Allan Butterfield, Tanea T Reed
Apr 29, 2015·Oxidative Medicine and Cellular Longevity·Cristina AngeloniSilvana Hrelia
Apr 9, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jan DobrovolnyJulie Bienertova-Vasku
Jul 6, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fabio A VigilMark S Shapiro
Apr 21, 2010·Journal of Neurochemistry·Ayman G MustafaEdward D Hall
Nov 21, 2017·Translational Stroke Research·Mohammad KhaksariNader Shahrokhi
Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Joseph A HankinRobert C Murphy

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