PMID: 9448623Feb 4, 1998Paper

Lazaroid improves intestinal blood flow in the rat during hyperdynamic bacteraemia

The British Journal of Surgery
R J KrysztopikR Neal Garrison

Abstract

Intestinal mucosal hypoperfusion and loss of barrier function during sepsis may contribute to maintaining the septic state. Free radicals are produced during sepsis and antioxidants improve survival from experimental sepsis. It is unclear whether endothelial cell injury from free radicals results in altered microvascular reactivity. Lazaroids are antioxidants which scavenge radicals and block lipid radical chain reactions. The authors sought to determine whether lazaroids altered the intestinal microvascular responses to sepsis. In vivo video microscopy was used to study the ileal microcirculation of the rat. A1 (inflow) arteriolar diameter and flow, A3 (premucosal) arteriolar diameters, and cardiac output were measured. Lazaroid or vehicle was infused before a bolus injection of live Escherichia coli or saline. Lazaroid alone had no effect on the intestinal vessels or haemodynamics. E. coli caused vasoconstriction (A1, -21 per cent, A3, -19 per cent of baseline) and hypoperfusion (-36 per cent) despite increased cardiac output (+31 per cent). Lazaroid significantly attenuated both constriction (A1, -11 per cent; A3, 10 to -1 per cent) and hypoperfusion (-15 per cent), but did not increase cardiac output (30 per cent). E. coli ...Continue Reading

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Citations

Jun 4, 2005·Microsurgery·Paul J Matheson, R Neal Garrison
Jul 14, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yun-Te ChangHong-Tai Chang
Dec 18, 2002·Archives of Biochemistry and Biophysics·Jong K Yun, Mark Kester
Aug 18, 2000·The Journal of Surgical Research·P J MathesonR N Garrison
Feb 24, 2000·The Journal of Pathology·H A LehrC J Kirkpatrick
Mar 25, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·E AlhanB V Kural

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