PMID: 641207Apr 1, 1978Paper

Lazy leucocyte syndrome--disorder of the granulocyte membrane?

Journal of Clinical Pathology
P H PinkertonJ S Senn

Abstract

An adult with long-standing neutropenia had the functional granulocyte abnormalities typical of the lazy leucocyte syndrome. Scanning electron microscopy of the patient's neutrophils showed alteration in the surface configuration of the cell with coarsening of the normal fine ruffles and the appearance of knob-like projections. Similar functional and anatomical changes were induced in normal neutrophils by treatment with vinblastine. The lazy leucocyte syndrome may be a consequence of altered membrane microfilamentous protein structure or function, and undue rigidity of the affected neutrophils may explain the clinicopathological features of the disease.

References

Sep 1, 1976·British Journal of Haematology·H El-Maalem, J Fletcher
Nov 1, 1975·The British Journal of Oral Surgery·T J Storrs
Nov 1, 1975·The British Journal of Surgery·J P BoltonN Menzies-Gow
Sep 1, 1975·Clinical Science and Molecular Medicine·W F ClarkV Parsons
Jun 1, 1969·Journal of Bacteriology·R I Lehrer, M J Cline
Sep 19, 1970·Lancet·H H Park, R A Good
May 1, 1973·The Journal of Clinical Investigation·G F Giordano, M A Lichtman
Mar 1, 1974·The Journal of Pediatrics·R L Baehner
Jun 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·O YlikorkalaP A Järvinen
Oct 29, 1970·The New England Journal of Medicine·M A Lichtman
Dec 1, 1971·The Journal of Clinical Investigation·R A Clark, H R Kimball
Sep 1, 1968·British Journal of Haematology·J J Cream
Oct 1, 1965·Arthritis and Rheumatism·S E Malawista
Oct 1, 1965·Arthritis and Rheumatism·J E Caner
Mar 24, 1955·Annals of the New York Academy of Sciences·J W REBUCK, J H CROWLEY
Jan 1, 1961·The Journal of Clinical Investigation·J W ATHENSM M WINTROBE

❮ Previous
Next ❯

Citations

Mar 1, 1983·Veterinary Immunology and Immunopathology·G S Smith, J H Lumsden
May 25, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Javed SheikhThomas D Coates
Nov 1, 1993·European Journal of Clinical Investigation·H BrenneisG M Hänsch
Oct 1, 1979·Blut·F PatroneC Sacchetti
May 1, 1991·Acta Pathologica Japonica·S KuramochiT Fujiwara
Oct 30, 2016·Blood·Frederick S Southwick
Nov 27, 2019·Journal of Clinical Immunology·Amos Etzioni, Hans D Ochs
Oct 30, 2016·Blood·Douglas B KuhnsSteven M Holland
Mar 6, 2021·Current Allergy and Asthma Reports·Elizabeth M Kang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.