Nov 2, 1977

LBA technique in the detection of chromosome variants. I. Chromosomes with known sites of Q variants

Human Genetics
S OkaM Arima

Abstract

A method is described (LBA method) which used DNA replication pattern in the detection of chromosome variants in man. In Part I, results on chromosomes with known sites of Q-variants, i.e., 5 pairs of acrocentrics, as well as 3 and 4, were presented. Fourty-one variants were detected in a total of 40 acrocentrics. Twenty-eight of them were detected only by the LBA technique; 11 of them being in short arms and 17 of them in centromeres. Seven variants, including 4 of those in satellites, were detected only in QFQ-stained metaphases. Six short-arm variants were observed by both methods. It appears that a sequential QFQ-LBA technique is very useful in the detection of variants in D- or G-group chromosomes.

Mentioned in this Paper

Study, Methodological
Centromere
Chromosomes, Human
Metaphase
Viral Satellite Organisms and Sequences
Chromosomes
Staining and Labeling
DNA Replication
Chromosomes, Human,13-15
Satellite Viruses

About this Paper

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