PMID: 2100211Jan 1, 1990Paper

LC determination of the diastereomers of 1-(beta-D-glucopyranosyl)phenobarbital in human urine

Journal of Pharmaceutical and Biomedical Analysis
W H SoineJ H Wood

Abstract

The "product enantioselectivity" associated with the urinary excretion of the phenobarbital N-glucoside conjugates has not been determined previously. A liquid chromatography method using gradient elution was developed for quantifying both phenobarbital N-glucoside conjugates, phenobarbital, and p-hydroxyphenobarbital. Following a single oral dose of phenobarbital to male Caucasian and Oriental subjects, both phenobarbital N-glucoside conjugates were observed in the urine. In seven subjects, 3.3-10.6% of the phenobarbital dose was detected as a single phenobarbital N-glucoside (S configuration at the C-5 position of the barbiturate ring). The other phenobarbital N-glucoside diastereomer accounted for less than 1.5% of the phenobarbital dose. The urinary excretion of the major phenobarbital N-glucoside diastereomer paralleled the urinary excretion of phenobarbital and was comparable in both Caucasian and Oriental subjects. These results indicate a pronounced selectivity for the formation and/or urinary excretion of the phenobarbital N-glucosides.

References

Mar 1, 1978·Acta paediatrica Scandinavica·L O BoréusN Kållberg
Jan 1, 1985·Journal of Clinical Pharmacology·T R BrowneD J Greenblatt

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Citations

May 21, 2004·European Journal of Drug Metabolism and Pharmacokinetics·Sheela G PaibirRobert A Fisher
Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·W H SoineT M England
May 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·V Nandi, W H Soine
Nov 1, 1994·British Journal of Clinical Pharmacology·I BernusM J Eadie
Feb 1, 1991·Journal of Pharmaceutical Sciences·W H SoineB E Agriesti

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