Lck-independent triggering of T-cell antigen receptor signal transduction by staphylococcal enterotoxins.

The Journal of Biological Chemistry
S YamasakiM Iwashima

Abstract

Superantigens (SAgs) activate T-cells in a manner specific to the Vbeta region of the T-cell antigen receptor. Stimulations by SAgs provoke drastic T-cell activation that leads to programmed cell death or the anergic state of responding cells. To characterize the signal transduction pathway initiated by SAgs, mutant lines derived from the human leukemic T-cell line Jurkat were tested for their reactivities against prototypic SAgs, staphylococcal enterotoxins. The J.CaM1.6 cell line, which lacks Lck expression and lost reactivity against T-cell antigen receptor-mediated stimulation, was activated by staphylococcal enterotoxins in a manner indistinguishable from the Jurkat cell line. In contrast, the J.45. 01 cell line, which lacks expression of functional CD45, showed severely impaired reactivity. The role of Lck appears to be replaced by another Src family protein-tyrosine kinase, Fyn. In J.CaM1.6 cells, Fyn was rapidly phosphorylated and activated after staphylococcal enterotoxin treatment. The kinase-inactive mutant of Fyn significantly suppressed the reactivity against staphylococcal enterotoxin E in J.CaM1.6 cells, and the expression of the active form of Fyn reconstituted reactivity against staphylococcal enterotoxin E in ...Continue Reading

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Citations

Jan 29, 2002·European Journal of Immunology·Silvia ValensinCosima T Baldari
Dec 19, 2000·Scandinavian Journal of Immunology·M A SheardY Takahama
Mar 18, 2003·Molecular and Cellular Biology·Sho YamasakiTakashi Saito
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Jan 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhigang LiJoaquín Madrenas
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Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gabriel Criado, Joaquín Madrenas

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