LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease

Free Radical Research
Yulia Y TyurinaValerian E Kagan

Abstract

Exposure to rotenone in vivo results in selective degeneration of dopaminergic neurons and development of neuropathologic features of Parkinson's disease (PD). As rotenone acts as an inhibitor of mitochondrial respiratory complex I, we employed oxidative lipidomics to assess oxidative metabolism of a mitochondria-specific phospholipid, cardiolipin (CL), in substantia nigra (SN) of exposed animals. We found a significant reduction in oxidizable polyunsaturated fatty acid (PUFA)-containing CL molecular species. We further revealed increased contents of mono-oxygenated CL species at late stages of the exposure. Notably, linoleic acid in sn-1 position was the major oxidation substrate yielding its mono-hydroxy- and epoxy-derivatives whereas more readily "oxidizable" fatty acid residues (arachidonic and docosahexaenoic acids) remained non-oxidized. Elevated levels of PUFA CLs were detected in plasma of rats exposed to rotenone. Characterization of oxidatively modified CL molecular species in SN and detection of PUFA-containing CL species in plasma may contribute to better understanding of the PD pathogenesis and lead to the development of new biomarkers of mitochondrial dysfunction associated with this disease.

References

Mar 1, 1990·Journal of Neurochemistry·A H SchapiraC D Marsden
Feb 1, 1989·Journal of Neurochemistry·D T DexterC D Marsden
Jan 1, 1988·Free Radical Research Communications·G N BaldenkovTs S Stoytchev
Apr 1, 1993·Journal of Bioenergetics and Biomembranes·N C Robinson
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·A YoritakaY Mizuno
Dec 20, 1996·Neuroscience Letters·M MogiT Nagatsu
May 26, 1998·Journal of Neuropathology and Experimental Neurology·P F GoodC W Olanow
Jan 19, 2002·IUBMB Life·J T GreenamyreA V Panov
Apr 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ranjita BetarbetJ Timothy Greenamyre
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gianguido Coffa, Alan R Brash
Mar 26, 2005·Brain Research. Molecular Brain Research·Claudia M TestaJ Timothy Greenamyre
May 14, 2005·Antioxidants & Redox Signaling·Todd B Sherer, J Timothy Greenamyre
Oct 26, 2005·The Journal of Biological Chemistry·Alexander PanovJ Timothy Greenamyre
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jordi BovéSerge Przedborski
Jan 13, 2006·Nature Chemical Biology·Valerian E KaganGregory G Borisenko
Jan 25, 2008·Free Radical Biology & Medicine·Yulia Y TyurinaValerian E Kagan
Nov 4, 2008·Nature Clinical Practice. Neurology·Claire Henchcliffe, M Flint Beal
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Dec 9, 2008·The International Journal of Biochemistry & Cell Biology·Mohammad Z AshrafEugene A Podrez
May 6, 2009·Biochimica Et Biophysica Acta·Michael Schlame, Mindong Ren
May 9, 2009·Antioxidants & Redox Signaling·Zhi Yao, Nicholas W Wood
Aug 19, 2009·Antioxidants & Redox Signaling·Valery N BochkovJohannes Stöckl
Sep 19, 2009·Methods in Molecular Biology·Michael A KiebishThomas N Seyfried
Jan 26, 2010·Trends in Pharmacological Sciences·J Timothy GreenamyrePier-Giorgio Mastroberardino
Apr 27, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yulia Y TyurinaValerian E Kagan
Aug 24, 2010·Molecular and Cellular Biochemistry·Klaudia JomovaMarian Valko
Feb 22, 2011·Trends in Immunology·Dmitri V KryskoPeter Vandenabeele
May 11, 2011·Antioxidants & Redox Signaling·Terina N Martinez, J Timothy Greenamyre
Aug 4, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Kai Michael KautherJens Carsten Möller
Jan 4, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chin-Song LuTu-Hsueh Yeh
Apr 3, 2012·Biochimica Et Biophysica Acta·Alejandro K Samhan-AriasAndrew A Amoscato
Dec 26, 2012·Frontiers in Genetics·Konstantinos Palikaras, Nektarios Tavernarakis
Jan 19, 2013·Free Radical Biology & Medicine·Laurie H Sanders, J Timothy Greenamyre
Jan 29, 2013·The International Journal of Biochemistry & Cell Biology·Martin JabůrekPetr Ježek
Mar 21, 2013·Current Atherosclerosis Reports·Maceler Aldrovandi, Valerie B O'Donnell

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Citations

Feb 14, 2016·Brain Research·Tamil Selvan AnthonymuthuHülya Bayır
Sep 24, 2015·Journal of Separation Science·Li YangHuwei Liu
Jun 11, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ameer Y TahaChristopher E Ramsden
Feb 1, 2017·The Journal of Cell Biology·Melissa VosPatrik Verstreken
Aug 12, 2017·Metabolites·Jesper F HavelundJan Bert Gramsbergen
Aug 25, 2017·Antioxidants & Redox Signaling·Yulia Y TyurinaValerian E Kagan
Jan 10, 2019·Cells·Helena XicoyGerard J M Martens
May 10, 2019·Journal of Leukocyte Biology·Yulia Y TyurinaValerian E Kagan
Jul 20, 2019·Journal of Neuroendocrinology·Estefania Acaz-FonsecaMariana Astiz
Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Wei QianBennett Van Houten
Feb 10, 2017·Neurology·Peter A LeWittUNKNOWN Parkinson Study Group–DATATOP Investigators
Jun 17, 2020·Expert Review of Neurotherapeutics·Roberta BonomoDebra J Skene
Jan 13, 2019·Molecular Neurodegeneration·Yaping Shao, Weidong Le
Feb 23, 2021·Frontiers in Neuroscience·Yanyan ZhangTian Tian
Mar 1, 2021·Trends in Endocrinology and Metabolism : TEM·Micol FalabellaRobert D S Pitceathly
Apr 11, 2021·Biogerontology·I AlmeidaA Nunes
Jul 25, 2021·International Journal of Molecular Sciences·Milena FaisCiro Iaccarino

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