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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

bioRxiv

Feb 21, 2014

Brendan K Bulik-SullivanBenjamin M. Neale

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Abstract

Both polygenicity (i.e. many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield inflated distributions of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between infla...read more

Mentioned in this Paper

Dysequilibrium Syndrome
Genetic Linkage
Population Group
Genome
Polygene
Genome-Wide Association Study
CFC1 gene
CFC1 wt Allele
Genomics
Stratification
43
3
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  • LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

    bioRxiv

    Feb 21, 2014

    Brendan K Bulik-SullivanBenjamin M. Neale

    PMID: 990002931

    DOI: 10.1101/002931

    Abstract

    Both polygenicity (i.e. many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield inflated distributions of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between infla...read more

    Mentioned in this Paper

    Dysequilibrium Syndrome
    Genetic Linkage
    Population Group
    Genome
    Polygene
    43
    3
    Paper Details
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