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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

bioRxiv

Feb 21, 2014

Brendan K Bulik-SullivanBenjamin M Neale

Abstract

Both polygenicity (i.e. many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield inflated distributions of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between infla...read more

Mentioned in this Paper

Stratification
Genetic Linkage
CFC1 wt Allele
Genome-Wide Association Study
Dysequilibrium Syndrome
Polygene
Genomics
Population Group
Genome
CFC1 gene
43
48
Paper Details
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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

bioRxiv

Feb 21, 2014

Brendan K Bulik-SullivanBenjamin M Neale

PMID: 990002931

DOI: 10.1101/002931

Abstract

Both polygenicity (i.e. many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield inflated distributions of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between infla...read more

Mentioned in this Paper

Stratification
Genetic Linkage
CFC1 wt Allele
Genome-Wide Association Study
Dysequilibrium Syndrome
Polygene
Genomics
Population Group
Genome
CFC1 gene
43
48
Paper Details
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  • finger pointing at paper

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    We're still populating references for this paper, please check back later.
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