PMID: 3745953Mar 1, 1986Paper

LDA-1: a ubiquitous noncollagenous lamina densa component of basement membrane detected by monoclonal antibody technique

The Journal of Investigative Dermatology
J D Fine, S Gay

Abstract

Using monoclonal antibody technology, a new basement membrane antigen, designated as LDA-1, has been identified. This antigen is expressed in all human tissues thus far examined; within skin it is detectable not only within the dermal-epidermal junction but also within dermal vascular and appendageal basement membranes. In addition to human skin, LDA-1 is also detectable within rabbit but not monkey, rat, mouse, guinea pig, or cow skin. This antigen has been ultrastructurally localized to the lamina densa and to a much lesser extent, the adjacent sublamina densa region. ELISA (enzyme-linked immunosorbent assay) revealed no cross-reactivity between LDA-1 and type IV collagen, laminin, fibronectin, and heparan sulfate proteoglycan. In vitro enzymatic studies suggest that LDA-1 is noncollagenous in nature.

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Citations

Jan 1, 1993·Archives of Dermatological Research·J KanitakisD Schmitt
Jan 1, 1989·Archives of Dermatological Research·Y HoriguchiJ R Couchman
Dec 1, 1986·Pediatric Dermatology·A T Lane
Dec 1, 1991·Journal of Cutaneous Pathology·J D Fine
Dec 1, 1990·The Histochemical Journal·J P CleutjensF T Bosman
Mar 1, 1988·The Journal of Investigative Dermatology·J D Fine, J R Couchman
Jul 1, 1992·The Journal of Investigative Dermatology·Y HoriguchiS Imamura

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