PMID: 3766114Jul 1, 1986Paper

LDH isoenzymes in CSF in the diagnosis of neonatal brain damage

Acta Neurologica Scandinavica
F FernándezM C Roche

Abstract

Lactate dehydrogenase isoenzymes in cerebrospinal fluid were measured during the first 24 h of life in 25 asphyctic neonates. The infants were subjected to clinical and developmental examinations for a mean follow-up period of 15.2 months. The mean values for cerebrospinal LDH2(MH3) and LDH3(M2H2) isoenzymes were significantly higher in asphyctic infants who died from hypoxic-ischemic encephalopathy or who survived but suffered neurologic sequelae, than they were in those asphyctic infants who survived and were normal in the follow-up studies. Therefore, the authors conclude that the lactate dehydrogenase isoenzyme pattern in cerebrospinal fluid may be of value when assessing anoxic brain damage.

References

Jan 1, 1983·Journal of Neurosurgery·R A Bakay, A A Ward
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Aug 1, 1958·A.M.A. Archives of Neurology and Psychiatry·J B GREENF M FORSTER
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