PMID: 11933112Apr 5, 2002Paper

LDH profiles of male and female rats treated with Vepacide

Phytotherapy Research : PTR
M F RahmanK Jamil

Abstract

In the present study we investigated the effect of vepacide, a neem-based compound, on the biochemical target enzyme lactate dehydrogenase (LDH) in different tissues of male and female albino Wistar rats treated orally with 80, 160 and 320 mg/kg (low, medium and high doses, respectively) for a period of 90 days. Prolonged administration of vepacide caused a significant increase of LDH activity in serum and lung tissues and a decrease in liver and kidney in both male and female rats when measured after 45 and 90 days of daily treatment. Females were more susceptible than males with regard to serum and kidney LDH showing sexual dimorphism in the treated rats. Recovery was observed in the affected enzyme after 28 days post treatment (withdrawal study). A positive correlation was observed with regard to this enzyme between serum and lung tissues, whereas for serum versus liver and kidney there was a negative correlation. The effect of vepacide was more pronounced in the lung tissue followed by liver and kidney tissues. Necrosis of the liver and kidney tissues was observed but in the lung tissue an increase in the LDH enzyme was seen. Therefore, it was concluded that the increase in LDH could be indicative of a stress adaptive respo...Continue Reading

References

Jan 1, 1992·Bulletin of Environmental Contamination and Toxicology·K Machera, E Kostakis
Feb 1, 1990·Bulletin of Environmental Contamination and Toxicology·A Janardhan, P Sisodia
Jan 1, 1988·Journal of Biochemical Toxicology·A R ShakooriM A Saleem
Jul 23, 1998·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·M MahboobK Jamil
Aug 31, 1999·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·M F RahmanK Jamil
Sep 4, 1999·Bulletin of Environmental Contamination and Toxicology·N S Oluah

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