LDHA upregulation independently predicts poor survival in lung adenocarcinoma, but not in lung squamous cell carcinoma

Future Oncology
Chengyong YuYingbo Li

Abstract

To investigate the potential prognostic value of LDHA in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Molecular, clinicopathological and survival data in Cancer Genome Atlas-Lung Cancer were obtained for secondary analysis. LDHA expression was significantly upregulated in both LUAD and LUSC compared with normal lung tissues. LUSC tissues had even higher LDHA expression compared with LUAD tissues. Increased LDHA expression was an independent prognostic indicator in terms of overall survival (hazard ratio: 1.547, 95% CI: 1.253-1.911; p < 0.001) and recurrence-free survival (hazard ratio: 1.486, 95% CI: 1.161-1.900; p = 0.002) in LUAD, but not in LUSC. LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC.

References

May 19, 2006·Cancer Research·Robert A GatenbyRobert J Gillies
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anne LeChi V Dang
Apr 5, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Theresia WilbertzSven Perner
Sep 21, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Munehide NakatsugawaNoriyuki Sato
Dec 14, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tineke W H MeijerJohan Bussink
Mar 13, 2012·NMR in Biomedicine·Guro F GiskeødegårdTone F Bathen
Jan 5, 2013·Cancer Research·Veronica EstrellaRobert J Gillies
Jan 11, 2013·Cancer Research·Stine Falsig Pedersen, Christian Stock
Feb 14, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yefei RongWenhui Lou
Aug 24, 2013·Nature Reviews. Cancer·Scott K ParksJacques Pouysségur
Aug 30, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Olga C J SchuurbiersJohan Bussink
Jan 15, 2015·International Journal of Oncology·Naoyuki OkabeHiroyuki Suzuki
Jan 24, 2015·Science·Mathias UhlénFredrik Pontén
Mar 7, 2015·Cancer Discovery
Apr 4, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aik T Ooi, Brigitte N Gomperts
Jul 10, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masaki ShimojiTetsuya Mitsudomi
Sep 7, 2016·The Breast : Official Journal of the European Society of Mastology·Xiaojia HuangXiaoming Xie
Feb 19, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Young Wha KohSeong Yong Park

❮ Previous
Next ❯

Citations

Feb 18, 2020·Future Medicinal Chemistry·Mark R WoodfordMehdi Mollapour
Dec 10, 2019·The American Journal of the Medical Sciences·Jiancheng LvQiang Lu
Jul 1, 2021·Cancer Management and Research·Xi WangHaijun Zhang
Jul 3, 2021·Scientific Reports·Ilir SherajSreeparna Banerjee

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq

Software Mentioned

GraphPad Prism
Xena browser
SPSS

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.