LDL-antioxidant pterocarpans from roots of Glycine max (L.) Merr

Journal of Agricultural and Food Chemistry
Jin Hwan LeeKi Hun Park

Abstract

The methanolic root extract of Glycine max (L.) Merr. was chromatographed, which yielded 10 flavonoids, including three isoflavones 1-3, five pterocarpans 4-8, one flavonol 9, and one anthocyanidin 10. All isolated compounds were examined for LDL-antioxidant activities using four different assay systems on the basis of Cu2+-mediated oxidation. Among them, seven compounds showed potent LDL-antioxidant activities in the thiobarbituric acid reactive substances (TBARS) assay, the lag time of conjugated diene formation, relative electrophoretic mobility (REM), and fragmentation of apoB-100 on copper-mediated LDL oxidation. Three pterocarpans 4, 6, and 7, never reported as LDL-antioxidant, showed potent activities with IC50 values of 19.8, 0.9, 45.0 microM, respectively, in comparison with probucol (IC50 = 5.6 microM) as positive control. Interestingly, coumestrol 6 (IC50 = 0.9 microM) showed 20 times more activity in the TBARS assay than genistein (IC50 = 30.1 microM) and daidzein (IC50 = 21.6 microM), representative antioxidants in soybean. Moreover, coumestrol 6 had an extended lag time of 190 min at 3.0 microM in measuring conjugated diene formation, while both genistein (120 min) and daidzein (93 min) lag times were extended to ...Continue Reading

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Citations

Jan 16, 2010·Journal of Chemical Ecology·Bridget F O'NeillMay R Berenbaum
May 7, 2011·Journal of Agricultural and Food Chemistry·Yan-Ying ZhouSheng-Hong Li
Oct 13, 2011·Journal of Agricultural and Food Chemistry·Heung Joo YukKi Hun Park
Nov 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Un-Hee KimTae-Sook Jeong
Nov 26, 2008·International Journal of Pharmaceutics·Camila FrancoValquiria Linck Bassani
Sep 6, 2015·Biochemical Pharmacology·Gaeun ParkKi Won Lee
Aug 12, 2014·Journal of Food Science·Feng HuLeif H Skibsted
Feb 18, 2017·International Journal of Molecular Sciences·Jong-Min HanTae-Sook Jeong
Jan 27, 2019·Journal of Asian Natural Products Research·Ran WenPeng-Fei Tu
Jul 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeong Yoon KimKi Hun Park
Dec 6, 2020·European Journal of Medicinal Chemistry·Fatemeh SalehianMehdi Khoobi
Apr 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yanbei TuChengwei He
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe PaladiniRosanna Stancanelli

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