PMID: 9523539Apr 2, 1998Paper

LDL apheresis for arteriosclerosis obliterans with occluded bypass graft: change in prostacyclin and effect on ischemic symptoms

Angiology
S MiiH Tsuruta

Abstract

To study the mechanism of efficacy of low-density lipoprotein (LDL) adsorption for arteriosclerosis obliterans (ASO), eight ASO patients without indication for bypass surgery underwent LDL apheresis twice a week for 5 weeks and the change in prostaglandin 12 (PGI2) and thromboxane A2 (TXA2) due to LDL apheresis was measured. The concentration of 6-keto-PGF1alpha, a metabolite of PGI2, in systemic venous blood significantly increased from 10.4 +/- 1.8 to 42.0 +/- 10.6 pg/mL (P<0.05) after one session of LDL apheresis, while no significant change of TXB2, a metabolite of TXA2, was encountered. The ratio of 6-keto-PGF1alpha/TXB2 also rose dramatically from 0.213 +/- 0.044 to 0.522 +/- 0.128 (P<0.05). In five patients, the ischemic clinical symptoms improved and both the concentration of 6-keto-PGF1alpha and the ratio of 6-keto-PGF1alpha/TXB2 increased significantly, whereas in three patients there was no effect on clinical symptoms and neither parameter changed. These results suggest that elevated production of PGI2 from vascular cells due to LDL apheresis might contribute to improvement of ischemic symptoms.

Citations

Oct 22, 2003·Journal of Clinical Apheresis·Shuzo KobayashiTakayasu Ohtake
Oct 14, 2006·Current Treatment Options in Cardiovascular Medicine·Patrick M Moriarty
Nov 11, 1999·Current Opinion in Lipidology·K Kajinami, H Mabuchi
Feb 11, 2004·Journal of Biomaterials Science. Polymer Edition·Yoshinobu MurakamiHiroo Iwata
Dec 4, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Motohiro KamimuraTadao Akizawa
Jan 5, 2008·Clinical and Experimental Nephrology·Shuzo Kobayashi
Feb 20, 2016·Endocrinology and Metabolism Clinics of North America·Patrick M Moriarty, Linda Hemphill
Oct 19, 2001·Mayo Clinic Proceedings·A VellaT O'Brien
Apr 15, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Alfonso RamunniPasquale Coratelli
Jul 31, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Akira Kawashima
Jul 31, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Motoyoshi Sato, Izumi Amano
Jul 5, 2006·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shuzo KobayashiTakayasu Ohtake
May 10, 2005·Journal of Clinical Apheresis·Shuzo KobayashiTakayasu Ohtake
Apr 19, 2011·Journal of Clinical Apheresis·Jannik RossenbachMichael J Koziolek
May 5, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Patrick MoriartyJohn Belmont
May 6, 2015·Cardiology Clinics·Patrick M Moriarty, Linda Hemphill
Apr 23, 2016·Clinical and Experimental Nephrology·Katsuya IshiyamaYoshio Taguma
Oct 14, 2009·Journal of Vascular Surgery·Elliot L ChaikofUNKNOWN Society for Vascular Surgery
Apr 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hassan DihaziGerhard A Mueller
Nov 17, 2005·The International Journal of Artificial Organs·M ValbonesiM R Ruzzenenti
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Jun 1, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Eri MusoYukio Yuzawa
Jul 4, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Katsuya Ishiyama, Toshinobu Sato

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