LDL-apheresis in homozygous LDL-receptor-defective familial hypercholesterolemia: the Munich experience

Atherosclerosis. Supplements
Christiane Keller

Abstract

23 patients, homozygotes for LDL-receptor defective familial hypercholesterolemia (FH), were diagnosed at our institute since 1960, eight of whom were heterozygous compounds. Three were lost to follow-up. Eight patients died at ages between 7 and 60 years due to cardiovascular complications, five from acute myocardial infarction, one from acute left heart failure due to severe aortic stenosis, and two from sudden death at their home. 12 patients have been treated with regular LDL-apheresis, 10 of these have continued the therapy for 8 to 27 years. The longest treatment has lasted for 31 years and is going on. The first patient started with plasma exchange in 1976.

Citations

Dec 25, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ingrid C Gelissen, Andrew J McLachlan
Sep 13, 2011·Epilepsia·Vinícius Rafael FunckMauro Schneider Oliveira
Mar 26, 2014·Pathologie-biologie·H EmonardS Dedieu
May 21, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael M PageJohn R Burnett
Feb 9, 2012·Cholesterol·Genovefa KolovouSophie Mavrogeni
May 6, 2015·Atherosclerosis. Supplements·Gilbert R Thompson
Nov 21, 2014·Current Atherosclerosis Reports·Claudia Stefanutti, Gilbert R Thompson
Jul 2, 2016·The American Journal of Cardiology·Mercedes MartinezLisa Cooper Hudgins
Dec 15, 2016·Paediatrics and International Child Health·Michael France
Jul 8, 2016·Journal of the American Heart Association·Anthony WangPeter P Toth
Jan 6, 2011·Current Opinion in Lipidology·Gilbert R Thompson
Aug 26, 2014·Deutsches Ärzteblatt International·Klaus G Parhofer
Aug 26, 2014·Deutsches Ärzteblatt International·Gerald KloseEberhard Windler
Mar 23, 2021·Hematology, Transfusion and Cell Therapy·Zehra Narlı ÖzdemirOsman İlhan
Sep 26, 2021·Current Opinion in Lipidology·Gilbert R Thompson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Jean-Bernard PalcouxBernard Roussel
© 2021 Meta ULC. All rights reserved