LDL-Cholesterol versus Glucose in Microvascular and Macrovascular Disease.

Clinical Chemistry
Frida Emanuelsson, Marianne Benn

Abstract

The causal relationships between increased concentrations of low density lipoprotein (LDL)-cholesterol and glucose and risk of ischemic heart disease are well established. The causal contributions of LDL-cholesterol and glucose to risk of peripheral micro- and macrovascular diseases are less studied, especially in prediabetic stages and in a general population setting. This review summarizes the current evidence for a causal contribution of LDL-cholesterol and glucose to risk of a spectrum of peripheral micro- and macrovascular diseases and reviews possible underlying disease mechanisms, including differences between vascular compartments, and finally discusses the clinical implications of these findings, including strategies for prevention and treatment. Combined lines of evidence suggest that LDL-cholesterol has a causal effect on risk of peripheral arterial disease and chronic kidney disease, both of which represent manifestations of macrovascular disease due to atherosclerosis and accumulation of LDL particles in the arterial wall. In contrast, there is limited evidence for a causal effect on risk of microvascular disease. Glucose has a causal effect on risk of both micro- and macrovascular disease. However, most evidence i...Continue Reading

References

May 1, 1988·Kidney International·J R Diamond, M J Karnovsky
Feb 19, 1998·The American Journal of Cardiology·T R PedersenT Haghfelt
Oct 16, 1999·Primary Care·B A Ramlo-Halsted, S V Edelman
Jul 4, 2001·Cerebrovascular Diseases·E B MathiesenK H Bønaa
Jun 21, 2002·American Heart Journal·Joanne M MurabitoPeter W f Wilson
Oct 25, 2002·The New England Journal of Medicine·David M Nathan
Feb 14, 2003·Archives of Ophthalmology·Hendrik A van LeidenBettine C P Polak
Mar 1, 1957·A.M.A. Archives of Ophthalmology·J R WOLTERR L PHILLIPS
Jul 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Kunimasa YagiHiroshi Mabuchi
Sep 11, 2004·Eye·H LeungP Mitchell
Jan 28, 2005·The New England Journal of Medicine·Solomon TesfayeUNKNOWN EURODIAB Prospective Complications Study Group
Jan 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·UNKNOWN Diabetes Prevention Program Research Group
Sep 4, 2007·Progress in Cardiovascular Diseases·Victor AboyansMichael H Criqui
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Apr 26, 2008·Atherosclerosis·Aaron R FolsomUNKNOWN Atherosclerosis Risk in Communities (ARIC) Study Investigators
Feb 21, 2009·Journal of the American College of Cardiology·Gabriela Orasanu, Jorge Plutzky
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Cornelia Hahn, Martin A Schwartz
Feb 12, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Dan ZieglerUNKNOWN KORA Study Group
Aug 6, 2009·Diabetologia·UNKNOWN Control GroupM Woodward
Mar 5, 2010·The New England Journal of Medicine·Elizabeth SelvinFrederick L Brancati
Jul 1, 2010·The New England Journal of Medicine·UNKNOWN ACCORD Study GroupLawrence J Fine
Oct 28, 2010·Diabetes Care·Stephen ColagiuriUNKNOWN DETECT-2 Collaboration Writing Group
Jul 8, 2011·Current Opinion in Lipidology·Handrean Soran, Paul N Durrington
Jun 16, 2012·Journal of the American College of Cardiology·Marianne BennBørge G Nordestgaard
Oct 25, 2012·JAMA : the Journal of the American Medical Association·Michel M JoostenKenneth J Mukamal
May 21, 2013·Journal of the American Society of Nephrology : JASN·Marcello TonelliUNKNOWN Alberta Kidney Disease Network
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
H Kapelrud, K F Hanssen
Journal of Cardiovascular Risk
H Miettinen, V Salomaa
Coronary Artery Disease
H Miettinen, V Salomaa
Hormone and Metabolic Research. Supplement Series
R J Jarrett
Diabetes Care
Bernd Stratmann, Diethelm Tschoepe
© 2021 Meta ULC. All rights reserved