LDL oxidative modifications in well- or moderately controlled type 2 diabetes

Diabetes/metabolism Research and Reviews
P G SchefferT Teerlink

Abstract

The aim of the study was to examine, by measurement of specific indicators of free radical-mediated oxidation of LDL, whether there is evidence of increased in vivo oxidation of LDL in type 2 diabetic patients, and to investigate their associations with carotid intima media thickness (IMT). In native LDL, we quantified five different products of LDL oxidation reflecting various stages of LDL oxidative modification in 38 individuals with well- or moderately controlled type 2 diabetes (HbA(1c) </= 8.5%) and 38 gender-matched subjects with normal glucose metabolism. Baseline conjugated dienes (BCD), 7-OH-glycero-phosphocholine (7-OH-GPC), lyso-phosphatidylcholine (lyso-PC), and ketocholesterol were determined in LDL, and circulating in vivo oxidized apolipoprotein B100 (Ox-apoB) was measured in plasma. The IMT of the carotid artery was measured by ultrasound. Borderline higher carotid IMT values were observed in individuals with diabetes (0.88 +/- 0.14 vs 0.83 +/- 0.11 mm, p = 0.06). LDL-ketocholesterol (45.5 +/- 19.4 vs 37.1 +/- 13.8 nmol/mmol LDL-cholesterol, p < 0.05) and Ox-apoB (25.3 +/- 5.5 vs 22.2 +/- 5.8 U/mmol LDL-cholesterol, p < 0.05) were significantly increased in diabetic patients. The concentration of BCD, 7-OH-GPC ...Continue Reading

Citations

Jul 24, 2010·Journal of Physiology and Biochemistry·María Isabel Burgos AlvesSoledad Parra Pallarés
Jan 11, 2013·Case Reports in Pediatrics·Aynur SolakBerhan Genç
Sep 20, 2008·Journal of Lipid Research·Leonard P van der ZwanPeter G Scheffer
Apr 25, 2006·Diabetes/metabolism Research and Reviews·Sónia BenítezJordi Ordóñez-Llanos
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Jul 23, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ana OteizaKaren Kristine Sørensen
May 29, 2021·Scientific Reports·Xiaoyu YangLei Liu

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