PMID: 7543026Jul 28, 1995Paper

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation

Cell
M Z KounnasD Strickland

Abstract

The secreted form of beta-amyloid precursor protein (APP) containing the Kunitz proteinase inhibitor (KPI) domain, also called protease nexin II, is internalized and degraded by cells. We show that the low density lipoprotein (LDL) receptor-related protein (LRP) is responsible for the endocytosis of secreted APP. APPs770 degradation is inhibited by an LRP antagonist called the receptor-associated protein (RAP) and by LRP antibodies and is greatly diminished in fibroblasts genetically deficient in LRP. APPs695, which lacks the KPI domain, is a poor LRP ligand. Since LRP also binds apolipoprotein E (apoE)-enriched lipoproteins and inheritance of the epsilon 4 allele of the apoE gene is a risk factor for Alzheimer's disease (AD), these data link in a single metabolic pathway two molecules strongly implicated in the pathophysiology of AD.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·W WascoF Solomon
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S TakahashiT Yamamoto
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G BuA L Schwartz
Feb 1, 1992·Molecular and Chemical Neuropathology·K C Breen
Jan 1, 1991·Journal of Neuroscience Research·K C BreenB H Anderton
Jan 1, 1992·Journal of Neuropathology and Experimental Neurology·B T HymanD Schenk
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R C KowalM S Brown
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D J Knauer, D D Cunningham
Apr 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G ZhengR T McCluskey
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·I WarshawskyA L Schwartz
Jul 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D K StricklandW S Argraves
Jan 13, 1995·The Journal of Biological Chemistry·J D MedhD A Chappell
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SaitoM G Farquhar
Sep 18, 1993·Lancet·J PoirierS Gauthier
May 16, 1994·Biochemical and Biophysical Research Communications·K L Johnson-WoodD B Schenk
Nov 1, 1993·The Journal of Clinical Investigation·A H SchmaierW E Van Nostrand

❮ Previous
Next ❯

Citations

Aug 11, 2000·Microscopy Research and Technique·E Van UdenE Masliah
Dec 1, 1996·Annals of Neurology·M J Garlepp, F L Mastaglia
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·E JönssonG Sedvall
Nov 1, 2011·Experimental Brain Research·Collin Y Ewald, Chris Li
Apr 17, 2008·Molecular Neurobiology·Hyang-Sook Hoe, G William Rebeck
Jun 23, 2004·Neurobiology of Disease·Cathy MitchelmoreNiels A Jensen
Feb 13, 2001·European Journal of Pharmacology·F Richard, P Amouyel
Dec 2, 2000·Journal of the Neurological Sciences·C J HuJ G Chang
Mar 14, 2001·Brain Research. Molecular Brain Research·G W RebeckB T Hyman
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Dec 10, 2002·Neurobiology of Aging·Ashley I Bush
Aug 21, 2003·Progress in Neurobiology·Paul R TurnerWickliffe C Abraham
Dec 1, 1996·Progress in Neurobiology·E MasliahW Samuel
Mar 12, 2004·Cancer Letters·Kenji Kadomatsu, Takashi Muramatsu
May 9, 1997·Neuroscience Letters·F Wavrant-DeVrièzeM C Chartier-Harlin
Apr 28, 1999·Neuroscience·A E ClatworthyG W Rebeck
Jun 6, 2003·Brain Research Bulletin·A RocchiL Murri
Jul 2, 2003·Cellular Signalling·Miguel Medina, Carlos G Dotti
Jun 21, 2002·Trends in Cell Biology·Anders Nykjaer, Thomas E Willnow
Feb 21, 2002·Trends in Endocrinology and Metabolism : TEM·Dudley K StricklandW Scott Argraves
Jan 11, 2001·Trends in Cardiovascular Medicine·J G NeelsP J Lenting
Feb 28, 2004·Trends in Cardiovascular Medicine·P G GrimsleyD A Owensby
Jun 26, 2003·The International Journal of Biochemistry & Cell Biology·Yan LingNoor Kalsheker
Apr 24, 1999·Neuropathology and Applied Neurobiology·E Storey, R Cappai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.