PMID: 6107936Oct 1, 1980Paper

LDS-25 as a discriminative stimulus for response selection by pigeons

Pharmacology, Biochemistry, and Behavior
T U Järbe

Abstract

Pigeons (N=4) were trained to discriminate between the effects induced by intramuscular (IM) injections of d-LSD and saline using a discrete-trial discrimination paradigm (choice between left and right hand key) in a conventional operant box. The solutions were administered IM 15 min prior to the sessions. A FR 15 schedule was in operation to produce food. Which of the two keys was correct on a given training session depended upon whether LSD or saline had been given. Three of the birds were trained and maintained with a dose of 40 microgram/kg of LSD and the fourth pigeon finally was maintained on 50 microgram/kg of LSD. The dose resulting in 50% LSD appropriate responding (ED50) was 18 microgram/kg and the median time-interval for the decay of the LSD stimulus (40 microgram/kg) was 84 min. Tests with psilocybin (ED50=0.55 mg/kg) and N,N-dimethyltryptamine (ED50=5.7 mg/kg) resulted in responding appropriate for the LSD training condition. Mescaline injections above 10 mg/kg severely suppressed responding. The few responses emitted after tests with 15 and 20 mg/kg of mescaline were directed to the LSD associated key. Tests with BOL (0.1 to 3 mg/kg) as well as three other psychotropic drugs (delta 9-tetrahydrocannabinol, morphin...Continue Reading

References

Jul 28, 1976·Psychopharmacology·T U JärbeB G Henriksson
Nov 1, 1977·Pharmacology, Biochemistry, and Behavior·M R Leberer, S C Fowler
Oct 1, 1978·Pharmacology, Biochemistry, and Behavior·T U Järbe
Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·B G HenrikssonT U Järbe
Nov 1, 1971·The Journal of Pharmacy and Pharmacology·R D SofiaH Barry
Dec 13, 1974·Nature·L PieriW Haefely
Dec 13, 1974·Nature·K Von HungenD F Hill
May 1, 1974·Pharmacology, Biochemistry, and Behavior·I D Hirschhorn, J A Rosecrans
Oct 1, 1967·Biochemical Pharmacology·J A RosecransD X Freedman

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Citations

Oct 17, 2012·Psychopharmacology·Theresa M CarbonaroMichael B Gatch
Oct 1, 1982·Pharmacology, Biochemistry, and Behavior·T U Järbe
Aug 11, 2007·Pharmacology, Biochemistry, and Behavior·J C WinterR A Rabin
Jan 25, 2011·Neuropharmacology·Adam L Halberstadt, Mark A Geyer
May 26, 2017·Behavioural Pharmacology·Michael B GatchMichael J Forster

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