PMID: 698163Sep 1, 1978Paper

Lead and iron absorption from rat small intestine: the effect of dietary Fe deficiency

The British Journal of Nutrition
I K Robertson, M Worwood

Abstract

1. When lead is administered in drinking-water iron-deficient rats retain more Pb than Fe-replete rats (Six & Goyer, 1972; Klauder & Petering, 1975). In the present study the relationship between the absorption of Pb and Fe was investigated. 2. Adult male rats were transfered to a milk-based diet fed with or without supplementary Fe (180 mg Fe/kg as ferrous sulphate). After 7--9 d the absorption of duodenally-administered 203Pb and 59Fe was measured as uptake of radioactivity from the gastrointestinal tract after 90 min. 59Fe absorption was increased in rats given the unsupplemented diet for 7 d and was further increased in rats kept on the diet for up to 7 weeks. 203Pb absorption was not consistently increased by either short- or long-term Fe deprivation. 3. Much of the 203Pb in homogenates of the upper small intestine was bound to soluble protein of which up to 85% was dialysable. In contrast little 59Fe was dialysable. Only a small proportion of the soluble musosal Pb was associated with ferritin during gel-filtration chromatography although 203Pb precipitated together with carrier rat-liver ferritin with an antibody to rat-liver ferritin. 4. There appeared to be no direct relationship between the transfer of Fe and Pb acros...Continue Reading

References

Dec 1, 1975·Environmental Health Perspectives·D S Klauder, H G Petering
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Mar 1, 1976·The British Journal of Nutrition·S M Triggs, R Bailey-Wood
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Citations

Aug 1, 1987·Environmental Health Perspectives·J C Barton, W J Huster
Jan 20, 2007·Toxicology and Applied Pharmacology·Qiang WangJingyuan Chen
Aug 25, 2004·The Science of the Total Environment·Wilson T KwongRichard D Semba
Oct 1, 1987·Biological Trace Element Research·J N Morrison, J Quarterman
Oct 25, 2001·Environmental Health Perspectives·A BradmanL R Goldman

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