Lead, attention, and impulsive behavior: changes in a fixed-ratio waiting-for-reward paradigm

Pharmacology, Biochemistry, and Behavior
B J Brockel, D A Cory-Slechta

Abstract

Similar to the effects observed in children diagnosed with attention deficit hyperactivity disorder (ADHD), experimental animals exposed to lead (Pb) exhibit behaviors attributed to "impulsivity" and "inability to inhibit inappropriate responding." Such behaviors have led some to suggest that Pb exposure is associated with attention deficit. Based on the hypothesis that attention deficits are related to an ineffectiveness of delayed reinforcement, this study examined the effects of chronic postweaning Pb exposure on an FR waiting-for-reward paradigm. Rats were exposed chronically from weaning to 0, 50, or 150 ppm Pb acetate in water and following 40 days of exposure, trained on a fixed-ratio (FR) wait behavioral baseline. A total of 50 lever press responses (FR 50) produced food delivery. After earning an FR pellet, "free" pellets could be obtained by waiting; emission of another lever press reinitiated the FR requirement. "Free" pellets were delivered at increasing intervals (2 s, 4 s, 6 s, etc.). Pb exposure increased response rates on the FR schedule and decreased the mean longest waiting time, but also resulted in a higher number of responses per reinforcer than exhibited by controls. These Pb-induced differences are consis...Continue Reading

References

Jan 1, 1979·Toxicology and Applied Pharmacology·D A Cory-Slechta, T Thompson
Jul 1, 1992·Neurotoxicology and Teratology·D C Rice
Apr 1, 1989·Behavioural Brain Research·R J Sutherland, A J Rodriguez
May 1, 1988·Neurotoxicology and Teratology·D C Rice, K F Karpinski
Sep 30, 1985·Toxicology and Applied Pharmacology·D C Rice, S G Gilbert
Apr 1, 1985·Toxicology and Applied Pharmacology·D A Cory-SlechtaC Cox
Aug 1, 1972·Experimental Neurology·B Jones, M Mishkin
Dec 1, 1983·Toxicology and Applied Pharmacology·D A Cory-SlechtaC Cox
Mar 1, 1983·Neuropathology and Applied Neurobiology·C WinderP D Lewis
Jan 1, 1982·International Archives of Occupational and Environmental Health·G WinnekeA Brockhaus
Mar 1, 1981·Journal of Pediatric Psychology·C R MilarL Boone
May 1, 1995·Journal of Child Psychology and Psychiatry, and Allied Disciplines·J B Schweitzer, B Sulzer-Azaroff
Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
Jan 1, 1993·Neurotoxicology and Teratology·K M Stiles, D C Bellinger
Jan 1, 1995·Experimental Brain Research·C E Stern, R E Passingham

❮ Previous
Next ❯

Citations

Jul 14, 2010·Biological Trace Element Research·Malarveni Damodaran Lakshmi Priya, Arumugam Geetha
Dec 14, 2011·Journal of Molecular Neuroscience : MN·J S SchneiderD W Anderson
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·B J Brockel, D A Cory-Slechta
Jun 5, 2003·Neurotoxicology·Helmut V B HirschDouglas M Ruden
Jun 7, 2000·Neurotoxicology and Teratology·R E MorganB J Strupp
Aug 22, 2001·Trends in Microbiology·J P Latgé
Jan 30, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Deborah A Cory-SlechtaJoshua L Allen
Aug 31, 2006·Behavioural Pharmacology·Walter AdrianiGiovanni Laviola
Jul 28, 2004·Developmental Neuropsychology·Richard L CanfieldDeborah A Cory-Slechta
Sep 11, 2010·Environmental Health Perspectives·Paul A EubigSusan L Schantz
Oct 23, 2008·Environmental Health Perspectives·Hui-Li WangDi-Yun Ruan
Oct 16, 2012·Environmental Health Perspectives·Joshua L AllenDeborah A Cory-Slechta
Dec 19, 2009·Environmental Health Perspectives·Ananya RoyKalpana Balakrishnan
Oct 4, 2008·Neurotoxicology and Teratology·Scott E Bowen, Phillip McDonald
Feb 20, 2009·The Journal of Comparative Neurology·Tyler Fortune, Diana I Lurie
Mar 19, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Virginia A Rauh, Amy E Margolis
Sep 2, 2005·Developmental Psychobiology·M Catalina CervantesYvon Delville
Jun 7, 2011·Neurotoxicology and Teratology·William H DribbenNuri Farber
Apr 1, 2018·Autism Research : Official Journal of the International Society for Autism Research·Jing WuJi-Sheng Han
Jan 30, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason R RichardsonGary W Miller
Dec 1, 2005·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Laura Hubbs-TaitDavid C Bellinger
Dec 31, 1998·Current Opinion in Neurology·M V Johnston, G W Goldstein
Jul 25, 2019·Frontiers in Behavioral Neuroscience·Cristian Perez-FernandezFernando Sánchez-Santed
Sep 28, 1999·Trends in Pharmacological Sciences·G W MillerM G Caron
May 23, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ayat Hussein B RashaidMahmoud Ahmad Bashtawi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Developmental Neuropsychology
Richard L CanfieldD A Cory-Slechta
Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
M J McIntoshJ L Reid
© 2022 Meta ULC. All rights reserved