Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors.

BioRxiv : the Preprint Server for Biology
S. IketaniD. D. Ho


We report the identification of three structurally diverse compounds - compound 4, GC376, and MAC-5576 - as inhibitors of the SARS-CoV-2 3CL protease. Structures of each of these compounds in complex with the protease revealed strategies for further development, as well as general principles for designing SARS-CoV-2 3CL protease inhibitors. These compounds may therefore serve as leads for the basis of building effective SARS-CoV-2 3CL protease inhibitors.


Mar 31, 2021·Virology Journal·Zachary A KrummYuxing Xia

Methods Mentioned

size exclusion chromatography

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