Lead exposure at an early age substantially increases lead retention in the rat

Environmental Health Perspectives
S HanJ D Bogden

Abstract

It has been hypothesized that the high rate of bone remodeling during childhood and the consequent high calcium and lead turnover result in a substantial reduction in bone lead stores so that much of the lead incorporated in bone during childhood does not persist into adulthood. We studied the effect of age at lead exposure on blood and organ concentrations of lead, calcium, and zinc 1-5 months after termination of lead ingestion. Blood and organ lead concentrations and contents 4 weeks after lead exposure ceased were significantly higher in the rats exposed beginning at 5 weeks of age than in those exposed beginning at 10 or 15 weeks old. Bone lead declined as the time since exposure increased. Despite this trend, the rats exposed when youngest had bone lead concentrations at 20 weeks after the termination of lead exposure that were higher than those of the other rats only 4 weeks after cessation of lead ingestion. Multiple regression analysis demonstrated that age at lead exposure remained a significant predictor of blood and organ lead concentrations and contents even after the inclusion of total lead consumed, body weight, and age at organ harvesting in the regression analysis. There were only small differences in organ cal...Continue Reading

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Citations

May 26, 1999·Environmental Health Perspectives·K BrueningJ D Bogden
Mar 22, 2005·Occupational and Environmental Medicine·E W HarvilleW Rogan
Mar 7, 2008·Journal of Exposure Science & Environmental Epidemiology·Claudia S RiedtSue A Shapses
Sep 19, 2002·Journal of Neuroscience Research·Marie-Gabrielle ZurichFlorianne Monnet-Tschudi
Apr 15, 2008·The Science of the Total Environment·Biljana Kalicanin, Zorica Ajduković
Jul 7, 2007·Human & Experimental Toxicology·F Monnet-TschudiP Honegger
Nov 2, 2011·Metallomics : Integrated Biometal Science·Diana GuimarãesJosé Paulo Santos
Feb 28, 1998·Environmental Health Perspectives·J D BogdenD B Louria

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