Lead exposure in preterm infants receiving red blood cell transfusions

Pediatric Research
Hijab ZubairiRachana Singh

Abstract

Preterm infants may inadvertently be exposed to lead from the packed red blood cell (pRBC) transfusions with almost no or very limited data available. The aim of the study was to quantify this exposure in preterm infants ≤30 wk gestational age (GA). Prospective cohort study, infants ≤30 wk GA were eligible, infants < 23 wk GA and known chromosomal diseases were excluded. Blood lead levels (BLLs) were obtained at birth, before and after each transfusion, and at discharge. BLLs were also obtained from the donor pRBC aliquot transfused. A linear mixed model analysis was done. Of 75 infants, 34 received a total of 126 pRBC transfusions. Each infant had an average of 3.7 transfusions. 92% of lead levels in the transfused aliquot were ≤ 5 mcg/dl, 6.8% were between 6-8 mcg/dl and 1 had a level of 56 mcg/dl. Average total lead load was 1.3 mcg/dl. For each 1 mcg/dl increase in transfused pRBC lead level, infant's post-transfusion BLL increased by 0.20 mcg/dl (95% CI: 0.07 mcg/dl, 0.33 mcg/dl; P = 0.002), adjusting for GA and birth weight. There was no significant increase in discharge BLLs, which were similar for both transfused and nontransfused infants. Post-transfusion infant BLLs correlate significantly with the transfused pRBCs le...Continue Reading

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Citations

Nov 13, 2015·Transfusion·Nicholas Newman, Patricia M Carey
Jul 15, 2015·Transfusion·Gilles DelageMarc Rhainds
Oct 28, 2019·Pediatric Research·Alison J FalckCynthia F Bearer
Jan 12, 2020·Transfusion Medicine·Maria AverinaBjørn Bolann
Oct 10, 2018·Pediatric Research·Sanaa Mohamed AlyDina El-Metwally
Jun 20, 2019·Pediatric Research·Alison J FalckCynthia F Bearer
Jan 27, 2021·Clinics in Laboratory Medicine·Patricia E Zerra, Cassandra D Josephson
Feb 6, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Samuel J OfforOrish E Orisakwe

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