PMID: 8938481Nov 1, 1996Paper

Lead: intestinal absorption and bone mobilization during lactation

Human & Experimental Toxicology
M Maldonado-VegaJ V Calderón-Salinas

Abstract

The aim of this study was to examine lead (Pb) intestinal absorption, its mobilization and redistribution during lactation in rats chronically exposed to lead. Lead and calcium (Ca) concentrations were measured in blood, milk, femurs, liver and kidney samples obtained from pregnant and lactating mother rats which were subjected to different schedules of exposure to Pb: 158 days before and during lactation (group A), 144 days before lactation (group B) and 14 days only during lactation (group C). Results were compared to those of non-pregnant but Pb-exposed matched rats and non-exposed control rats. In groups A and B during lactation, Pb in blood (PbB), liver and kidney increased while Pb in bone decreased. Since there was not an external source of Pb in group B during lactation, the results indicate resorption of Pb in bone as the main source of Pb in the organism. In group A, there was an additional increase of PbB when compared to group B as a result of Pb intestinal absorption. In group C a significant increase in PbB due to intestinal absorption and deposit in bone was found when compared to non-pregnant 144 days old rats, suggesting that the three processes intestinal absorption, bone resorption and bone absorption were ta...Continue Reading

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Citations

Mar 4, 1999·Environmental Health Perspectives·J D Osterloh, T J Kelly
Mar 18, 2004·Reviews on Environmental Health·Linda M HeathJohn W Edwards
Aug 1, 2012·Archives of Environmental & Occupational Health·Ikaraoha Chidiebere IkechukwuMbadiwe Nkeiruka Chigaekwu
Apr 16, 1998·Environmental Health Perspectives·M A PerazaL T Rael
Jul 22, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L G Navarro-MorenoJ V Calderón-Salinas
Jun 19, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Rendón-RamirezJ V Calderón-Salinas
Oct 15, 2005·Toxicology and Applied Pharmacology·G E Cortina-RamírezJ V Calderón-Salinas
Nov 5, 2002·Human & Experimental Toxicology·M Maldonado VegaJ V Calderón Salinas
Jun 18, 1999·Human & Experimental Toxicology·J V Calderón-SalinasC E Hernández-Luna
May 6, 2019·Environmental Science and Pollution Research International·Sergey MiroshnikovMikhail Poberukhin
Apr 24, 1999·Human & Experimental Toxicology·J V Calderón-SalinasM T González-Martínez

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