Lead (Pb) neurotoxicology and cognition

Applied Neuropsychology. Child
Michael P Santa MariaJoshua Kline

Abstract

Lead (Pb) is a neurotoxic substance. While it is widely understood that Pb exposure in early childhood adversely impacts neurodevelopment and intelligence, other aspects of cognition that are negatively affected, and the neuroanatomy and neurophysiology underlying Pb-related cognitive impairment are not widely appreciated by clinicians. This critical review gives a broad synopsis of the current literature in the field. The means by which Pb enters the body, crosses the blood-brain barrier, alters brain structure and function, and consequently impacts measurable aspects of cognition are reviewed. We detail research relating exposure to Pb at various levels in early childhood to deficits in IQ, academic achievement, executive functioning, and cognition in general. Clinical disorders associated with early Pb exposure, common and uncommon routes of environmental exposure, and potential confounding variables are discussed. We discuss methods of statistically accounting for these issues in the context of potential means of relying upon existing research and specific individuals' known blood Pb levels to make reasonable calculations regarding Pb-related compromise of intellectual functioning for individuals in clinical settings.

References

Oct 1, 1992·Journal of Child Neurology·R G Feldman, R F White
May 7, 1992·The New England Journal of Medicine·R Hohlfeld, A G Engel
Feb 2, 1990·JAMA : the Journal of the American Medical Association·H L Needleman, C A Gatsonis
Nov 1, 1990·Archives of Environmental Health·C B Ernhart, T Greene
Oct 1, 1989·Developmental Medicine and Child Neurology·G H CooneyC Carter
Dec 1, 1989·Immunology Today·M W MakgobaS Shaw
Mar 1, 1989·Neurotoxicology and Teratology·G H CooneyC Carter
Nov 1, 1988·Journal of Child Psychology and Psychiatry, and Allied Disciplines·D M FergussonN G Kinzett
Apr 23, 1987·The New England Journal of Medicine·D BellingerM Rabinowitz
Jan 1, 1973·Journal of Clinical Psychology·J M Sattler, J J Ryan
Apr 1, 1968·Archives of Disease in Childhood·S F Cahalane
Aug 1, 1994·Journal of Developmental and Behavioral Pediatrics : JDBP·A W WolfB Lozoff
Mar 3, 1994·Biochimica Et Biophysica Acta·J P VosB M Gadella
Jan 1, 1993·Neurotoxicology and Teratology·K M Stiles, D C Bellinger
Jan 1, 1996·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·G WinnekeU Krämer
Jan 1, 1996·International Journal of Legal Medicine·M MorinagaM Kageura
Sep 23, 1997·Toxicology and Applied Pharmacology·L E Kerper, P M Hinkle
Dec 31, 1997·Environmental Health Perspectives·G A WassermanJ H Graziano
Dec 16, 1998·Occupational and Environmental Medicine·L StokesW E Kaye
Feb 17, 2000·Environmental Research·W I MantonT J Kuehnemann
Apr 11, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·W ZhengW S Blaner
Aug 4, 2001·Toxicology and Applied Pharmacology·W DengR D Poretz
Jan 30, 2002·The Journal of Pediatrics·Bruce P LanphearShirley Eberle
Jan 31, 2002·Biological Trace Element Research·B Nehru, P Sidhu
Dec 4, 2002·Neurotoxicology and Teratology·Herbert L NeedlemanMichael J Tobin
Dec 13, 2002·Brain : a Journal of Neurology·Theodore I Lidsky, Jay S Schneider
Apr 18, 2003·The New England Journal of Medicine·Richard L CanfieldBruce P Lanphear
Jun 20, 2003·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Richard L CanfieldCharles R Henderson
Nov 1, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·A S Kaufman
Nov 1, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·A S Kaufman
Jan 30, 2004·Annual Review of Medicine·Herbert Needleman
Apr 29, 2004·Neurotoxicology and Teratology·Lisa M ChiodoJoseph L Jacobson
Jul 28, 2004·Developmental Neuropsychology·Richard L CanfieldDeborah A Cory-Slechta

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Citations

Sep 24, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yu SunXingyin Liu
Jan 2, 2021·International Journal of Environmental Research and Public Health·Amal K Mitra, Charkarra Anderson-Lewis
Nov 25, 2020·Neural Regeneration Research·Jian-Zhu BoYan-Shu Zhang
Dec 30, 2020·Antioxidants·Faraz Ahmad, Ping Liu
Jan 26, 2021·Toxicological Research·Ulisses C AraujoCláudio C Filgueiras
Mar 28, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Malavika LPraveen Sharma
Jun 29, 2021·Journal of Chemical Neuroanatomy·Rosa María Vigueras-VillaseñorJulio César Rojas-Castañeda
Sep 24, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Yuanyuan ZhengLijun Wu

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Methods Mentioned

BETA
x-ray
biopsy
imaging techniques

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