PMID: 9644976Jun 30, 1998Paper

Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase

Trends in Biochemical Sciences
M WarrenP M Shoolingin-Jordan

Abstract

In mammals and yeast, 5-aminolaevulinic acid dehydratase is a zinc-dependent enzyme that catalyses the synthesis of porphobilinogen-the pyrrole building block that is incorporated into all modified tetrapyrroles, including haem, chlorophyll and vitamin B12. The X-ray structure of this enzyme reveals how substitution of the catalytically important zinc ion by lead inactivates the enzyme and causes a form of pseudo-porphyria.

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