Lead poisoning-induced hypertensive crisis managed by prazosin: a case report

Iranian Red Crescent Medical Journal
Bita DadpourMohammad Moshiri

Abstract

Chronic lead exposure is known to be a risk factor for hypertension (HTN). No specific medication is recommended for the treatment of lead-induced hypertension (LIHTN). Our patient was a male admitted with the chief complaint of chronic abdominal pain. His whole blood lead level was reported to be 1961 µg/L. He also mentioned a previous history of HTN managed by propranolol (10 mg, TDS). He discharged himself by giving written consent and 19 days later, he was re-admitted due to high blood pressure of 220/140 mmHg. His Blood pressure (BP) was decreased to 180/110 mmHg with sublingual captopril; but, in maintenance therapy, higher doses of captopril could not further decrease BP. Amlodipine was tried which was discontinued due to the patient intolerance. Prazosin was then administered in gradual increasing doses up to 1 mg twice a day and captopril was tapered. We would like to suggest that LIHTN may better be managed by alpha blockers compared with converting enzyme inhibitors.

References

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Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Omid MehrpourMohammad Abdollahi

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Citations

Sep 22, 2016·Iranian Red Crescent Medical Journal·Hadi Ansarihadipour, Mohamadreza Bayatiani
Jul 23, 2019·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Samaneh NakhaeeOmid Mehrpour
Jun 27, 2020·Drug and Chemical Toxicology·Alireza AmirabadizadehOmid Mehrpour
Jul 18, 2020·Scientific Reports·Nasim ZamaniAli-Asghar Kolahi
Oct 7, 2017·Substance Abuse Treatment, Prevention, and Policy·Mohammad Mahdi HayatbakhshOmid Mehrpour
Aug 13, 2017·Basic & Clinical Pharmacology & Toxicology·Samira AlinejadOmid Mehrpour
Aug 21, 2021·Toxicology and Applied Pharmacology·Saeed SamarghandianOmid Mehrpour

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