PMID: 3761012Aug 1, 1986Paper

Lead toxicity in chicks: interactions with dietary methionine and choline

The Journal of Nutrition
D M Latta, W E Donaldson

Abstract

Two factorial experiments were conducted to study the effects of dietary methionine and choline on lead toxicity in chicks. Dietary variables were 0.3 or 0.63% (experiment 1) or 0.23 or 0.75% methionine (experiment 2); 0 or 1000 ppm lead (as Pb acetate X 3H2O); and 1130 or 3300 mg/kg (experiment 1) or 396 or 1266 mg/kg choline (experiment 2). In both experiments, lead depressed growth while methionine stimulated growth. Growth depression by lead was less with methionine-adequate than with methionine-inadequate diets. There were no differences in growth with the choline-marginal or choline-excess diets. In experiment 2, the methionine x lead interaction for growth was observed with choline-adequate but not with choline-inadequate diets. Lead-induced depression of growth was exacerbated by added choline when methionine-inadequate diets were fed. With methionine-adequate diets, choline level had no effect on the lead-induced depression of growth. Hepatic nonprotein sulfhydryl (NPSH) concentrations were increased by both supplemental methionine and lead with no interaction. Choline levels had no effect on NPSH. Dietary methionine significantly lowered Pb concentration of kidney and muscle but not of bone, liver or blood. Choline ha...Continue Reading

Citations

Dec 1, 1991·Biological Trace Element Research·W E Donaldson
Apr 1, 1989·Biological Trace Element Research·W E Donaldson, C McGowan
Mar 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·W E Donaldson, S O Knowles

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