Leaflet manual of external beam radiation therapy for hepatocellular carcinoma: a review of the indications, evidences, and clinical trials

OncoTargets and Therapy
Chai Hong Rim, Won Sup Yoon

Abstract

The use of external beam radiation therapy (EBRT) in the treatment of hepatocellular carcinoma (HCC), which was rarely performed due to liver toxicity with a previous technique, has increased. Palliation of portal vein thrombosis, supplementation for insufficient transarterial chemoembolization, and provision of new curative opportunities using stereotactic body radiotherapy are the potential indications for use of EBRT. The mechanism of EBRT treatment, with its radiobiological and physical perspectives, differs from those of conventional medical treatment or surgery. Therefore, understanding the effects of EBRT may be unfamiliar to physicians other than radiation oncologists, especially in the field of HCC, where EBRT has recently begun to be applied. The first objective of this review was to concisely explain the indications for use of EBRT for HCC for all physicians treating HCC. Therefore, this review focuses on the therapeutic outcomes rather than the detailed biological and physical background. We also reviewed recent clinical trials that may extend the indications for use of EBRT. Finally, we reviewed the current clinical practice guidelines for the treatment of HCC and discuss the current recommendations and future pers...Continue Reading

Citations

Dec 6, 2018·International Journal of Molecular Sciences·Tetsuo NakajimaMitsuru Nenoi
Mar 6, 2019·International Journal of Radiation Biology·Chai Hong RimChul Yong Kim
Jul 12, 2019·Journal of Clinical and Translational Hepatology·Chien Pong Chen
Dec 31, 2020·Journal of Hepatocellular Carcinoma·Han Ah Lee, Chai Hong Rim
May 1, 2021·Biology·Han Ah Lee On Behalf Of The Korean Liver Cancer Study Group

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Clinical Trials Mentioned

NCT02724475
NCT01901692

Software Mentioned

Scopus

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