Leakage of catecholamines from rabbit cerebrospinal fluid following intracerebroventricular injection

Clinical and Experimental Pharmacology & Physiology
C MaccarroneC Raper


The intracerebroventricular (i.c.v.) injection of (-)-isoprenaline and the selective beta 1-adrenoceptor agonist, RO363, elicited reproducible dose-related increases in heart rate in unanaesthetized and anaesthetized rabbits. (-)-Isoprenaline produced vasodepressor effects in unanaesthetized animals, whereas both catecholamines decreased blood pressure in anaesthetized rabbits. Pretreatment with guanethidine sulphate (5 mg/kg i.v.) reduced but did not abolish the tachycardia elicited by i.c.v. RO363, whereas heart rate responses to i.c.v. (-)-isoprenaline were unaffected. Pretreatment of anaesthetized rabbits with hexamethonium bromide (10 mg/kg i.v.) did not markedly affect the tachycardia elicited by i.c.v. RO363 and reduced the response to i.c.v. (-)-isoprenaline in only one out of five experiments. The results suggest that there is a marked leakage of centrally administered catecholamines into the peripheral circulation and that the rabbit may be unsuited for examining centrally mediated cardiovascular effects of catecholamines.


Nov 15, 1978·European Journal of Pharmacology·C RaperD Iakovidis
Feb 1, 1973·The Australian Journal of Experimental Biology and Medical Science·S W White, R J McRitchie
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Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Ruth A DuffyJean E Lachowicz

Related Concepts

Adrenergic beta-Agonists
Guanethidine Sulfate (2: 1), 14C-Labeled
Hexamethonium Compounds
Injections, Intraventricular

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