Lean mass, grip strength and risk of type 2 diabetes: a bi-directional Mendelian randomisation study

Diabetologia
Chris Ho Ching YeungC Mary Schooling

Abstract

Muscle mass and strength may protect against type 2 diabetes as a sink for glucose disposal. In randomised controlled trials, resistance training improves glucose metabolism in people with the metabolic syndrome. Whether increasing muscle mass and strength protects against diabetes in the general population is unknown. We assessed the effect of markers of muscle mass and strength on diabetes and glycaemic traits using bi-directional Mendelian randomisation. Inverse variance weighting estimates were obtained by applying genetic variants that predict male lean mass, female lean mass and grip strength, obtained from the UK Biobank GWAS, to the largest available case-control study of diabetes (DIAbetes Genetics Replication And Meta-analysis [DIAGRAM]; n = 74,124 cases and 824,006 controls) and to a study of glycaemic traits (Meta-Analyses of Glucose and Insulin-related traits Consortium [MAGIC]). Conversely, we also applied genetic variants that predict diabetes, HbA1c, fasting glucose, fasting insulin and HOMA-B to UK Biobank summary statistics for genetic association with lean mass and grip strength. As sensitivity analyses we used weighted median, Mendelian randomisation (MR)-Egger and Mendelian Randomization Pleiotropy RESidual...Continue Reading

References

Jun 1, 2005·The International Journal of Biochemistry & Cell Biology·Aaron G Smith, George E O Muscat
Nov 14, 2006·Lancet·Kun-Ho YoonHo-Young Son
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Jun 16, 2009·European Journal of Pediatrics·Anne E WindRaoul H H Engelbert
Oct 31, 2009·Lancet·Ambady RamachandranChamukuttan Snehalatha
Sep 4, 2010·International Journal of Epidemiology·Brandon L PierceTyler J Vanderweele
Dec 7, 2010·Annals of Epidemiology·C Mary SchoolingGabriel M Leung
Feb 5, 2011·Circulation. Cardiovascular Genetics·Christopher D AndersonJonathan Rosand
Jun 20, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D BannUNKNOWN NSHD Scientific and Data Collection Team
Oct 26, 2013·International Journal of Epidemiology·Marie-Jo A BrionPeter M Visscher
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Rita Rastogi KalyaniLuigi Ferrucci
Oct 14, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·W W HouC M Schooling
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
May 14, 2016·Metabolism: Clinical and Experimental·Joule J LiRobert J Adams
Jun 19, 2016·Bioinformatics·James R StaleyAdam S Butterworth
Dec 3, 2016·Nucleic Acids Research·Jacqueline MacArthurHelen Parkinson
Jul 21, 2017·Nature Communications·M Carola ZillikensDouglas P Kiel
Dec 12, 2017·Current Epidemiology Reports·Jie ZhengGeorge Davey Smith
Apr 25, 2018·Scientific Reports·Emmi TikkanenErik Ingelsson

❮ Previous
Next ❯

Citations

Mar 20, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Heidi E E ZweersSusanne Leij-Halfwerk
Apr 11, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kazuhiro SugimotoTakuro Shimbo
Jun 17, 2020·Diabetes/metabolism Research and Reviews·Setor K KunutsorJari A Laukkanen
May 30, 2020·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Irfan Ahmed
Dec 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Ebaa Al-OzairiStuart R Gray
Mar 16, 2021·Journal of the American Heart Association·Jakob TarpUlf Ekelund
Apr 16, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Maryam KazemiPhilip D Chilibeck
May 30, 2021·Tropical Medicine & International Health : TM & IH·Anthony Muchai ManyaraJason M R Gill
Jul 29, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Charis Bridger StaatzRebecca Hardy
Jul 11, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Eva GesteiroMarcela González-Gross
Aug 18, 2021·Expert Review of Endocrinology & Metabolism·Hidetaka Hamasaki
Aug 24, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Jang Yel Shin, Jung Soo Lim
Oct 19, 2021·Tropical Medicine & International Health : TM & IH·Chrispin Mahala MandaYukiko Wagatsuma
Dec 26, 2021·Journal of Cachexia, Sarcopenia and Muscle·Solange Parra-SotoFrederick K Ho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.