Lean tissue mass wasting is associated with increased risk of mortality among women with pulmonary tuberculosis in urban Uganda.

Annals of Epidemiology
Ezekiel MupereChristopher Whalen

Abstract

We assessed the impact of wasting on survival in patients with tuberculosis by using a precise height-normalized lean tissue mass index (LMI) estimated by bioelectrical impedance analysis and body mass index (BMI). In a retrospective cohort study, 747 adult pulmonary patients with tuberculosis who were screened for HIV and nutritional status were followed for survival. Of 747 patients, 310 had baseline wasting by BMI (kg/m(2)) and 103 by LMI (kg/m(2)). Total deaths were 105. Among men with reduced BMI, risk of death was 70% greater (hazard ratio [HR] 1.7, 95% confidence interval [95% CI] 1.03-2.81) than in men with normal BMI. Survival did not differ by LMI among men (HR 1.1; 95% CI 0.5-2.9). In women, both the BMI and LMI were associated with survival. Among women with reduced BMI, risk of death was 80% greater (HR 1.8; 95% CI 0.9-3.5) than in women with normal BMI; risk of death was 5-fold greater (HR 5.0; 95% CI 1.6-15.9) for women with low LMI compared with women with normal LMI. Wasting assessed by reduced BMI is associated with an increased risk for death among both men and women whereas reduced LMI is among women with tuberculosis.

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Citations

Dec 11, 2013·PloS One·Melissa R NyendakUNKNOWN Tuberculosis Research Unit and the Tuberculosis Trials Consortium
Apr 26, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Amara E EzeamamaChristopher C Whalen
Jan 6, 2018·American Journal of Epidemiology·Catherine M SteinHarriet Mayanja-Kizza
May 26, 2020·Expert Review of Anti-infective Therapy·George PrayGod
May 18, 2021·Osteoporosis and Sarcopenia·Ching-Lung CheungChih-Hsing Wu

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