Learned preference and aversion for complete and isoleucine-devoid diets in rats

Physiology & Behavior
M Naito-HoopesQ R Rogers

Abstract

Choice tests using flavored solutions were conducted to demonstrate a learned preference or aversion in rats fed replete (complete) or isoleucine (ILE)-devoid diets. In the first learning trial, rats demonstrated a preference for the flavored solutions paired with the replete diet at 6 and 24 h (p < 0.001), and an aversion for the solutions paired with the ILE-devoid diet at 6 h (p < 0.05). In the second trial, using a different concentration of tastant, rats ingested significantly more of the flavored solution paired with the replete diet at 24 h (11.4 +/- 3.0 g vs. 5.4 +/- 1.0 g, respectively; p < 0.05), and significantly more of a novel flavored solution than of the solution paired with the ILE-devoid diet at 24 h (12.4 +/- 2.4 g vs. 1.7 +/- 0.6 g, respectively; p < 0.001). These results suggest that learning contributes to the rat's ability to self-select diets that promote growth, and that a learning paradigm pairing flavored solutions with complete and indispensible amino acid-devoid diets may be used to demonstrate learned preferences and aversions for such diets in rats.

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Citations

Feb 11, 2003·Physiology & Behavior·Ahmed BensaïdGilles Fromentin
May 1, 1996·The British Journal of Nutrition·G Fromentin, S Nicolaidis
Mar 3, 2007·Annual Review of Nutrition·Dorothy W GietzenTracy G Anthony
Mar 22, 2007·American Journal of Physiology. Endocrinology and Metabolism·Christopher D MorrisonRoy J Martin
Nov 27, 2018·Physiological Reviews·Lindsey A Schier, Alan C Spector
Sep 29, 2020·Journal of Cachexia, Sarcopenia and Muscle·Brennan OlsonAaron J Grossberg
Jul 31, 2004·The Journal of Nutrition·Quinton R RogersJames G Morris

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