PMID: 2510907Nov 20, 1989Paper

Learning about rules but not about reward is impaired following lesions of the cholinergic projection to the hippocampus

Brain Research
R M RidleyH F Baker

Abstract

Common marmosets with bilateral ibotenic acid-induced destruction of the neurones of the vertical limb of the diagonal band of Broca, which provide the major cholinergic input to the hippocampal formation, were impaired on the acquisition but not on the retention of a repeated-trial visuospatial discrimination learning task. They were also impaired on serial spatial reversal learning (but not on serial object reversal learning), on acquisition of a trial-independent successive concurrent discrimination using novel objects (but not on acquisition of a comparable discrimination in which two familiar objects had predictable reward value) and were unable to acquire a difficult conditional object discrimination. It is argued that the role of the hippocampus is in the acquisition but not the retention of ruled-based behaviour (which includes spatial responding) in contrast to the acquisition of discriminations based on stimulus-reward association formation.

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Citations

May 1, 1992·Pharmacology, Biochemistry, and Behavior·G J CareyM B Tyers
Jan 1, 1991·Brain Research. Brain Research Reviews·R M Ridley, H F Baker
Apr 18, 1994·Behavioural Brain Research·M A Peinado-Manzano
Dec 10, 1998·British Journal of Pharmacology·J A HarderR M Ridley
Apr 12, 2003·Brain : a Journal of Neurology·P J BrastedS P Wise
Oct 1, 1992·British Journal of Pharmacology·R J HargreavesS B Freedman
Jan 1, 1997·Annual Review of Psychology·B J Everitt, T W Robbins
Mar 1, 1992·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·C D FrithH F Baker
Feb 15, 2011·Behavioural Brain Research·Lianne RobinsonGernot Riedel
Feb 21, 1994·Brain Research·A R BentivoglioA Albanese
Oct 22, 2010·Neurobiology of Aging·Cathleen HaenseWolf-Dieter Heiss
Aug 16, 2016·Behavioural Brain Research·Joshua J TremelJulie A Fiez
Oct 12, 2014·Psychonomic Bulletin & Review·Arne Dietrich, Hilde Haider
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F CasamentiG Pepeu

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