Learning about Time within the Spinal Cord II: Evidence that Temporal Regularity Is Encoded by a Spinal Oscillator

Frontiers in Behavioral Neuroscience
Kuan H LeeJames W Grau

Abstract

How a stimulus impacts spinal cord function depends upon temporal relations. When intermittent noxious stimulation (shock) is applied and the interval between shock pulses is varied (unpredictable), it induces a lasting alteration that inhibits adaptive learning. If the same stimulus is applied in a temporally regular (predictable) manner, the capacity to learn is preserved and a protective/restorative effect is engaged that counters the adverse effect of variable stimulation. Sensitivity to temporal relations implies a capacity to encode time. This study explores how spinal neurons discriminate variable and fixed spaced stimulation. Communication with the brain was blocked by means of a spinal transection and adaptive capacity was tested using an instrumental learning task. In this task, subjects must learn to maintain a hind limb in a flexed position to minimize shock exposure. To evaluate the possibility that a distinct class of afferent fibers provide a sensory cue for regularity, we manipulated the temporal relation between shocks given to two dermatomes (leg and tail). Evidence for timing emerged when the stimuli were applied in a coherent manner across dermatomes, implying that a central (spinal) process detects regulari...Continue Reading

References

Jan 15, 1979·Experimental Brain Research·S Grillner, P Zangger
Jun 1, 1991·Journal of Applied Physiology·R R RoyV R Edgerton
May 26, 1987·Brain Research·H Barbeau, S Rossignol
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·Z Boulos, M Terman
Jul 1, 1996·Journal of Neurophysiology·M BélangerS Rossignol
Jul 11, 1998·Journal of Neurophysiology·R D De LeonV R Edgerton
Feb 3, 1999·Annals of the New York Academy of Sciences·O Kiehn, O Kjaerulff
Feb 13, 1999·Cell·J C Dunlap
Apr 14, 1999·Gait & Posture·J Duysens, Van de Crommert HW
Dec 1, 2001·Current Biology : CB·E Marder, D Bucher
Nov 9, 2002·Journal of Neurophysiology·Fernando Gómez-PinillaV Reggie Edgerton
Apr 8, 2004·Brain : a Journal of Neurology·Karen J HutchinsonD Michele Basso
Apr 15, 2004·Current Opinion in Neurobiology·Richard B Ivry, Rebecca M C Spencer
Jun 26, 2004·Annual Review of Neuroscience·V Reggie EdgertonRoland R Roy
Jun 26, 2004·Annual Review of Neuroscience·Michael D Mauk, Dean V Buonomano
Feb 3, 2005·Journal of Neurotrauma·James W GrauRajesh C Miranda
May 17, 2005·Journal of Neurotrauma·David S K MagnusonDarlene A Burke
Jun 14, 2005·Nature Reviews. Genetics·Deborah Bell-PedersenMark J Zoran
May 9, 2006·Neuroscience·A R FergusonJ W Grau
Jun 17, 2006·Annual Review of Neuroscience·Ole Kiehn
Jan 26, 2007·Acta Physiologica·H Hultborn, J B Nielsen
Feb 3, 2007·Neuron·Uma R Karmarkar, Dean V Buonomano
Sep 21, 2007·Nature Reviews. Neuroscience·Erik D Herzog
Feb 27, 2008·Behavioral Neuroscience·Michelle A HookJames W Grau
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Grégory BarrièreSerge Rossignol
Jun 10, 2008·Trends in Cognitive Sciences·Richard B Ivry, John E Schlerf
Sep 2, 2009·Brain Research Reviews·Pierre A Guertin
Apr 8, 2011·Annual Review of Neuroscience·Serge Rossignol, Alain Frigon
Apr 27, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Alain Frigon
Jun 2, 2012·Science·Rubia van den BrandGrégoire Courtine
Aug 31, 2012·Frontiers in Physiology·James W GrauAdam R Ferguson
Oct 23, 2012·Frontiers in Physiology·Adam R FergusonJames W Grau

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