Learning and memory disabilities in young adult rats from mildly zinc deficient dams

Physiology & Behavior
E S HalasM J Eberhardt

Abstract

Three experiments were conducted to test the behavior of the offspring of rat dams (ZD) fed a mildly zinc deficient diet (10.0 micrograms Zn/g) during pregnancy and lactation. Since zinc deficiency causes anorexia, a second group of rat dams (PF) was fed the same quantity of the diet during gestation and lactation as was consumed by their ZD mates. A third group of rats (AL) was fed the diet ad lib during gestation and lactation. The PF and AL dams were given zinc supplemented (25.0 micrograms Zn/ml) drinking water whereas the ZD dams were given double distilled, deionized drinking water. After weaning, the offspring of all dams were fed Purina Laboratory Chow ad lib until they were 100 days old. The offspring were then reduced to 85% of their ad lib weight and tested on a 17-arm radial maze for memory and learning. In Experiments 1 and 2, the ZD males suffered a significant learning deficit when compared to the AL males. Whereas the PF males suffered a significant learning impairment in Experiment 1, the learning deficit of the PF group was not as severe as the deficit of the ZD group. There was no impairment in reference (long-term) memory for any of the groups. In Experiment 3, significant differences in working (short-term)...Continue Reading

References

Jan 1, 1979·Neuropsychologia·D S Olton, B C Papas
Nov 1, 1977·Physiology & Behavior·E S HalasH H Sandstead
May 1, 1979·Physiology & Behavior·E S HalasH H Sandstead
Jan 13, 1978·Brain Research·D S OltonF H Gage
Apr 1, 1978·Journal of Comparative and Physiological Psychology·G Winocur, J Olds
May 1, 1978·Physiology & Behavior·D S Olton, M A Werz
Feb 1, 1975·Pediatric Research·G J FosmireH H Sandstead
Sep 18, 1975·Nature·E S HalasH H Sandstead
Sep 1, 1972·The American Journal of Medicine·J A HalstedJ G Reinhold
Oct 18, 1974·Brain Research·E FjerdingstadE J Fjerdingstad
Dec 1, 1972·Pediatric Research·K M HambidgeJ D Baum
Jun 1, 1972·Journal of Neurochemistry·I L Crawford, J D Connor
Nov 3, 1980·Brain Research·J T BeckerD S Olton

❮ Previous
Next ❯

Citations

Nov 15, 2002·Journal of Biomedical Science·R Bonfante-CabarcasJ A Moreno-Yanes
Feb 3, 2007·Eating and Weight Disorders : EWD·C L Birmingham, S Gritzner
Feb 3, 2009·Biological Trace Element Research·S Tahmasebi BoroujeniM Javadian
Nov 19, 2011·Neurotoxicity Research·J R Nuttall, P I Oteiza
Jun 2, 2005·Progress in Neurobiology·Eugenio MocchegianiMarco Malavolta
Mar 29, 2001·Physiology & Behavior·K A KellerJ A Coffield
Aug 1, 1997·Physiology & Behavior·S Z XiaA K Guo
Dec 13, 2000·Brain Research. Brain Research Reviews·A Takeda
Dec 29, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·T Y Turner, M R Soliman
Jun 1, 1994·Environmental Health Perspectives·C T WalshP J Fraker
Apr 17, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Alireza MahmoudianJavad Hami
May 31, 2014·Clinics in Perinatology·Katie M Pfister, Sara E Ramel
Dec 3, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Harold H Sandstead, Jeanne H Freeland-Graves
Mar 28, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Atsushi TakedaNaoto Oku
May 21, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Emily HoRobert L Tanguay
Nov 26, 2009·Neurochemistry International·Mitsugu WatanabeAtsushi Takeda
Nov 26, 2008·Brain Research Reviews·Amy S Nakashima, Richard H Dyck
Sep 2, 2008·Physiology & Behavior·Heather R Mattila, Brian H Smith
Dec 15, 2006·Behavioural Brain Research·Atsushi TakedaNaoto Oku
Jul 15, 2015·The Journal of Nutritional Biochemistry·Johnathan R NuttallPatricia I Oteiza
Apr 5, 2012·BioFactors·Shannon D Gower-Winter, Cathy W Levenson
Jan 27, 2005·Neurochemistry International·Atsushi TakedaNaoto Oku
Jul 23, 2009·Synapse·Byron K Y Bitanihirwe, Miles G Cunningham
Nov 23, 2007·Experimental Gerontology·Wolfgang Maret, Harold H Sandstead
Aug 25, 2012·The Journal of Nutritional Biochemistry·Hisaka KuritaChiharu Tohyama
Dec 4, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Rohit SethCathy W Levenson
Jan 23, 2015·Frontiers in Behavioral Neuroscience·Simone HagmeyerAndreas Martin Grabrucker
Oct 25, 2016·Neuroscience·Bo Young ChoiSang Won Suh
Sep 4, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sung Ryul LeeJin Han
Aug 29, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Atsushi TakedaNaoto Oku

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.