Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task

Behavioural Brain Research
Miroljub PopovićWillem Hendrik Gispen

Abstract

Diabetes mellitus is associated with disturbances of cognitive functioning. The aim of this study was to examine cognitive functioning in diabetic rats using the 'Can test', a novel spatial/object learning and memory task, without the use of aversive stimuli. Rats were trained to select a single rewarded can from seven cans. Mild water deprivation provided the motivation to obtain the reward (0.3 ml of water). After 5 days of baseline training, in which the rewarded can was marked by its surface and position in an open field, the animals were divided into two groups. Diabetes was induced in one group, by an intravenous injection of streptozotocin. Retention of baseline training was tested at 2-weekly intervals for 10 weeks. Next, two adapted versions of the task were used, with 4 days of training in each version. The rewarded can was a soft-drink can with coloured print. In a 'simple visual task' the soft-drink can was placed among six white cans, whereas in a 'complex visual task' it was placed among six soft-drink cans from different brands with distinct prints. In diabetic rats the number of correct responses was lower and number of reference and working memory errors higher than in controls in the various versions of the te...Continue Reading

References

Dec 1, 1992·Diabetes Care·A I VinikL B Colen
Jul 1, 1994·Diabetologia·G J BiesselsW H Gispen
Sep 25, 1999·Diabetes/metabolism Research and Reviews·A K Kumagai
Nov 14, 2000·Trends in Neurosciences·W H Gispen, G J Biessels

❮ Previous
Next ❯

Citations

Aug 11, 2012·Acta neurologica Belgica·Saida HaiderDarakhshan J Haleem
May 15, 2002·European Journal of Pharmacology·Geert Jan BiesselsWillem Hendrik Gispen
Aug 28, 2003·Lancet Neurology·Joshua P Klein, Stephen G Waxman
Sep 12, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yanina RevsinMelly S Oitzl
Jun 19, 2007·Antioxidants & Redox Signaling·Masahiro OkouchiTak Yee Aw
Jan 10, 2014·Psychopharmacology·Lourdes Valencia-TorresVladimir Orduña
Oct 9, 2015·The Quarterly Journal of Experimental Psychology : QJEP·Lucy G ChekeNicola S Clayton
Oct 27, 2012·Neuroscience Letters·Adam R TaylorJames I Koenig
Dec 17, 2015·ACS Chemical Neuroscience·Joana M GasparAntonio F Ambrosio
Dec 2, 2008·Behavioural Brain Research·Edgardo O AlvarezFlavia Saravia
Jun 11, 2004·Pediatric Diabetes·Christopher M Ryan
Apr 20, 2004·European Journal of Pharmacology·Wei-Qin ZhaoDaniel L Alkon
Mar 1, 2006·Life Sciences·Jan M DielemanCor J Kalkman
Oct 21, 2005·Neurobiology of Aging·Claude Messier
Apr 15, 2016·International Journal of Preventive Medicine·Akram SadeghiZahra Hejazi
Apr 3, 2013·Neurobiology of Aging·Tristano PancaniOlivier Thibault
Jul 23, 2013·European Journal of Pharmacology·Olivier ThibaultNada M Porter
Jul 24, 2012·Neuroscience and Biobehavioral Reviews·Therese A KostenHongjoo J Lee
Dec 6, 2017·Journal of Pediatric Neurosciences·Javad HamiMehran Hosseini
May 7, 2008·Expert Review of Neurotherapeutics·David F CechettoShawn N Whitehead
Sep 26, 2019·Arquivos de neuro-psiquiatria·Eduardo Fernandes BondanRosemari Otton
May 17, 2014·Metabolic Brain Disease·Aarti NagayachIshan Patro
Mar 10, 2017·Expert Review of Clinical Pharmacology·Sherifa A Hamed
Feb 21, 2014·F1000Research·Shaimaa N AminIbrahim Mohamady
Jul 22, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Praveen K KodumuriAnil Kumar Pandey
Jun 26, 2021·Pharmacology & Therapeutics·Sorabh Sharma, Craig E Brown

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.