Learning as a model for neural plasticity in major depression

Biological Psychiatry
Christoph NissenClaus Normann

Abstract

The neuroplasticity hypothesis of depression proposes that a dysfunction of neural plasticity-the basic ability of living organisms to adapt their neural function and structure to external and internal cues-might represent a final common pathway underlying the biological and clinical characteristics of the disorder. This study examined learning and memory as correlates of long-term synaptic plasticity in humans to further test the neuroplasticity hypothesis of depression. Learning in three tasks, for which memory consolidation has been shown to depend on local synaptic refinement in areas of interest (hippocampus-dependent declarative word-pair learning, amygdala-dependent fear conditioning, and primary-cortex-dependent visual texture discrimination), was assessed in 23 inpatients who met International Classification of Disease, 10th Revision, criteria for severe unipolar depression and 35 nondepressed comparison subjects. Depressed subjects showed a significant deficit in declarative memory consolidation and enhanced fear acquisition as indicated by skin conductance responses to conditioned stimuli, in comparison with nondepressed subjects. Depressed subjects demonstrated impaired visual discrimination at baseline, not allowin...Continue Reading

References

Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A Karni, D Sagi
Jul 1, 1987·Behavioral and Neural Biology·M R FoyR F Thompson
May 1, 1981·Psychophysiology·D C FowlesP H Venables
Jun 1, 1994·Scientific American·J E LeDoux
Apr 1, 1994·Current Opinion in Neurobiology·D Sagi, D Tanne
Jan 1, 1993·Journal of Psychosomatic Research·S LevensteinA Andreoli
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y I ShelineM W Vannier
Aug 1, 1997·Current Opinion in Neurobiology·A Karni, G Bertini
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Nov 7, 2000·Biological Psychiatry·F H Gage
May 2, 2001·Nature Reviews. Neuroscience·A J CalderA W Young
Sep 25, 2001·Neuron·C D GilbertR E Crist
May 2, 2002·Biological Psychiatry·Thomas FrodlHans-Jürgen Möller
May 10, 2002·Hippocampus·Constantine PavlidesBruce S McEwen
Aug 16, 2002·Bipolar Disorders·Maurizio PopoliGiorgio Racagni
Oct 31, 2002·Reviews in the Neurosciences·Réne Garcia
Nov 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sophie SchwartzChris Frith
Jan 29, 2003·Current Opinion in Pharmacology·Michael SpeddingLaszlo Harsing
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Glenda M MacQueenL Trevor Young
Mar 4, 2003·The British Journal of Psychiatry : the Journal of Mental Science·Richard J PorterAllan H Young
May 20, 2003·The European Journal of Neuroscience·Deborah N AlfarezHarm J Krugers
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Aug 6, 2003·The American Journal of Psychiatry·Yvette I ShelineHelena C Kraemer
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tianming Yang, John H R Maunsell
Mar 17, 2004·Current Opinion in Pharmacology·Eero Castrén
Apr 2, 2004·The American Journal of Psychiatry·Stephanie CampbellGlenda M MacQueen
Jul 3, 2004·Biological Psychiatry·Meena VythilingamJ Douglas Bremner
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Oct 12, 2004·Hippocampus·Daniel T RadeckiTimothy J Teyler
Oct 30, 2004·The American Journal of Psychiatry·Poul Videbech, Barbara Ravnkilde
Feb 11, 2005·Cerebral Cortex·Matthew P WalkerSeung-Schik Yoo
Mar 2, 2005·Nature Reviews. Neuroscience·Eero Castrén

❮ Previous
Next ❯

Citations

Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hyeon SonRonald S Duman
Jan 25, 2016·Sleep Medicine Reviews·Elias WolfChristoph Nissen
Nov 9, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yoshihiro TanakaJotaro Akiyoshi
May 17, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Frauke NeesHerta Flor
Oct 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marion KuhnChristoph Nissen
Mar 16, 2013·Depression and Anxiety·Dawn F IonescuCarlos A Zarate
Aug 24, 2013·The European Journal of Neuroscience·Jennifer L McGuireLuke R Johnson
May 1, 2012·Biological Psychiatry·Hanna E StevensFlora M Vaccarino
Jun 7, 2014·Brain Structure & Function·Raffaele CacciagliaFrauke Nees
Jun 24, 2015·Neuropsychologia·Yong-Il ShinMichael A Nitsche
Apr 7, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·E PasparakisP Bitsios
Jun 2, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andre Russowsky BrunoniAlberto Priori
Feb 7, 2015·Neuropsychologia·Yong-Il ShinMichael A Nitsche
Sep 12, 2012·The International Journal of Neuropsychopharmacology·Alfredo Ramos-MiguelJesús A García-Sevilla
Nov 2, 2011·The International Journal of Neuropsychopharmacology·Tzuri LifschytzBernard Lerer
Sep 25, 2014·Frontiers in Human Neuroscience·Daphne J HoltRoger B H Tootell
Apr 12, 2014·Frontiers in Behavioral Neuroscience·Tereza NekovarovaRichard Rokyta
Mar 8, 2014·Memory·Pauline DibbetsElisabeth A T Evers
Aug 25, 2016·Neurobiology of Learning and Memory·K MahatiB S Shankaranarayana Rao
Nov 3, 2016·Social Cognitive and Affective Neuroscience·Nicole WiggertJens Blechert
Jun 21, 2017·ASN Neuro·Mariagiovanna CantoneRita Bella
Aug 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaoling GuoJiaxu Chen
May 29, 2018·Psychological Medicine·Jennifer R GoldschmiedRoseanne Armitage
Mar 15, 2018·Experimental Neurobiology·Doyoung ParkSue-Hyun Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.