Learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis

ANZ Journal of Surgery
Yeqian HuangDavid L Morris

Abstract

Combined cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) has been considered as a standard approach for peritoneal surface malignancy. This study aims to assess the learning curve of this combined approach. Prospectively collected data of our first 800 consecutive patients treated by CRS and PIC between January 1996 and July 2014 were retrospectively reviewed. Eight hundred patients were divided into two groups and eight groups for comparison. A significant difference was defined as P < 0.05. A significant increase in the rate of the completeness of cytoreduction (CC) score-0 from 74.0% to 83.0% was seen with a reduction in rates of other CC scores. Also, there was a decreasing trend in mean blood transfusion units. The rate of viscus perforation, fistula formation and small bowel obstruction was significantly lower in the recent 400 patients. However, there was a significant increase in the incidence of deep venous thrombosis and pulmonary embolism. There was an improvement in the 5-year survival rate for patients with colorectal cancer, pseudomyxoma peritonei and mesothelioma. Our findings demonstrate a learning curve associated with the combined approach of CRS and PIC. With adequate experien...Continue Reading

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Citations

Mar 2, 2016·Journal of Anesthesia History·Lori Dangler
Jul 1, 2017·ANZ Journal of Surgery·Corina BehrenbruchAlexander Heriot
Nov 30, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Xin-Bao LiYan Li
Mar 20, 2019·Indian Journal of Surgical Oncology·Yutaka YonemuraSachio Fushida
Feb 24, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Cécile LoaecFrédéric Dumont

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