Learning deficits and suppression of the cell proliferation in the hippocampal dentate gyrus of offspring are attenuated by maternal chewing during prenatal stress

Neuroscience Letters
Mika OnishiKin-ya Kubo

Abstract

Prenatal stress in dams induces learning deficits and suppresses neurogenesis in the hippocampal dentate gyrus (DG) of offspring via increasing corticosterone levels in the dam. Chewing under stressful conditions prevents stress-induced behavioral impairments and morphologic changes. Here, we examined whether chewing during prenatal stress prevents the stress-induced learning deficits and the suppression of cell proliferation in the hippocampal DG in adult offspring. Pregnant mice were exposed to restraint stress beginning on day 12 of pregnancy and continuing until delivery. Half of the dams were given a wooden stick to chew on during restraint. The pups were raised to adulthood, and learning ability and cell proliferation in the hippocampal DG were assessed. In dams, chewing during prenatal stress attenuated the stress-induced increase in plasma corticosterone levels. In the adult offspring, prenatal stress impaired learning and decreased cell proliferation in the DG, whereas maternal chewing during prenatal stress significantly attenuated the prenatal stress-induced learning deficits and decreased cell proliferation in the DG in their offspring. These findings suggest that maternal chewing during prenatal stress is an effect...Continue Reading

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Citations

Mar 7, 2015·The Tohoku Journal of Experimental Medicine·Minori KurahashiKin-ya Kubo
Jun 20, 2015·BioMed Research International·Kin-ya KuboHuayue Chen
Aug 5, 2017·International Journal of Molecular Sciences·Kagaku AzumaKin-Ya Kubo
Oct 3, 2018·Biological & Pharmaceutical Bulletin·Kagaku AzumaKin-Ya Kubo
May 30, 2019·International Dental Journal·Priscila ChuhuaicuraRamón Fuentes
Dec 16, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Xinli XiangTao Duan
Dec 28, 2019·The Japanese Dental Science Review·Juri SarutaKeiichi Tsukinoki

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