PMID: 8608583Nov 1, 1995Paper

Learning deficits in congenitally hydrocephalic rats and prevention by early shunt treatment

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
H C JonesN G Harris

Abstract

Shunt surgery is the usual treatment for infantile hydrocephalus; however, the extent to which it avoids subsequent neurological deficits is uncertain. The effect of early-onset hydrocephalus was tested in H-Tx rats using the Morris water maze. Spatial learning was assessed at 21 days after birth in control (n = 18), hydrocephalic (n = 18) and hydrocephalic rats shunt-treated at 4-5 (n = 7) or at 10-12 days of life (n = 13). The time taken to find a hidden platform was measured in five trials on 2 consecutive days and the data analyzed by one- and two-way ANOVA and t-tests. The latencies of the control rats decreased significantly between the first and second trial on the 1st day, and learning was retained until the 2nd day. The hydrocephalic group had longer latencies than controls on both days, with no significant decrease between any trials. Performance was not significantly different between the two shunt groups. Overall, the shunted rats had latencies which were not significantly different from controls but were significantly lower than hydrocephalics. Despite this, the shunted rats did not perform as well as the controls. It is concluded that, although shunt treatment improved learning, some effects of early-onset hydroce...Continue Reading

References

Nov 1, 1991·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·W C HaniganP Bradle
Jun 1, 1991·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·T Miyazawa, K Sato
Sep 1, 1990·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S OiM Mochizuki
Jul 1, 1988·Neuropathology and Applied Neurobiology·H C Jones, R M Bucknall
Jan 1, 1988·Acta Neuropathologica·M R Del Bigio, J E Bruni
Jan 1, 1985·Behavioral and Neural Biology·F Schenk
Jan 1, 1985·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H K ZeinerR V Smith
May 1, 1984·Journal of Neuroscience Methods·R Morris
Oct 1, 1981·Archives of Neurology·M DennisR P Humphreys
Jul 1, 1994·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·N G HarrisS Patel
Jan 1, 1994·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·K SudaH Arai
Jan 1, 1994·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·J F Hirsch

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Citations

Feb 26, 2003·Annals of Neurology·Marc R Del BigioTerry Enno
Apr 27, 2010·Developmental Disabilities Research Reviews·Marc R Del Bigio
Mar 7, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael T WilliamsWeihong Yuan
Sep 4, 2012·Fluids and Barriers of the CNS·Funmilayo Eniola OlopadeAnna-Leena Sirén
Jul 1, 2005·Neurosurgery·Michael KieferWolf-Ingo Steudel
Apr 7, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Carlos Henrique Rocha CatalãoLuiza da Silva Lopes

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