Learning Domain-Invariant Representations of Histological Images

Frontiers in Medicine
Maxime W LafargeMitko Veta

Abstract

Histological images present high appearance variability due to inconsistent latent parameters related to the preparation and scanning procedure of histological slides, as well as the inherent biological variability of tissues. Machine-learning models are trained with images from a limited set of domains, and are expected to generalize to images from unseen domains. Methodological design choices have to be made in order to yield domain invariance and proper generalization. In digital pathology, standard approaches focus either on ad-hoc normalization of the latent parameters based on prior knowledge, such as staining normalization, or aim at anticipating new variations of these parameters via data augmentation. Since every histological image originates from a unique data distribution, we propose to consider every histological slide of the training data as a domain and investigated the alternative approach of domain-adversarial training to learn features that are invariant to this available domain information. We carried out a comparative analysis with staining normalization and data augmentation on two different tasks: generalization to images acquired in unseen pathology labs for mitosis detection and generalization to unseen o...Continue Reading

References

Mar 1, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Arnout C RuifrokDennis A Johnston
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Dec 31, 2014·Medical Image Analysis·Mitko VetaJosien P W Pluim
Feb 11, 2016·IEEE Transactions on Medical Imaging·Korsuk SirinukunwattanaNasir M Rajpoot
Mar 14, 2017·IEEE Transactions on Medical Imaging·Neeraj KumarAmit Sethi
Apr 15, 2017·IEEE Journal of Biomedical and Health Informatics·Yue HuangGustavo Rohde
Jul 12, 2018·IEEE Transactions on Pattern Analysis and Machine Intelligence·Artem RozantsevPascal Fua

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Citations

May 21, 2021·Journal of Pathology Informatics·André HomeyerPeter Hufnagl

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