Learning dynamics of electrophysiological brain signals during human fear conditioning.

NeuroImage
Matthias F J SperlErik M Mueller

Abstract

Electrophysiological studies in rodents allow recording neural activity during threats with high temporal and spatial precision. Although fMRI has helped translate insights about the anatomy of underlying brain circuits to humans, the temporal dynamics of neural fear processes remain opaque and require EEG. To date, studies on electrophysiological brain signals in humans have helped to elucidate underlying perceptual and attentional processes, but have widely ignored how fear memory traces evolve over time. The low signal-to-noise ratio of EEG demands aggregations across high numbers of trials, which will wash out transient neurobiological processes that are induced by learning and prone to habituation. Here, our goal was to unravel the plasticity and temporal emergence of EEG responses during fear conditioning. To this end, we developed a new sequential-set fear conditioning paradigm that comprises three successive acquisition and extinction phases, each with a novel CS+/CS- set. Each set consists of two different neutral faces on different background colors which serve as CS+ and CS-, respectively. Thereby, this design provides sufficient trials for EEG analyses while tripling the relative amount of trials that tap into more ...Continue Reading

References

Jan 1, 1991·Electroencephalography and Clinical Neurophysiology·S Yamaguchi, R T Knight
Feb 1, 1989·Electroencephalography and Clinical Neurophysiology·F PerrinJ F Echallier
Jun 1, 1980·Electroencephalography and Clinical Neurophysiology·D Lehmann, W Skrandies
Jan 1, 1984·Progress in Neurobiology·D Lehmann, W Skrandies
Jan 1, 1994·Brain Topography·C M Gomez GonzalezS A Hillyard
Jan 1, 1995·Annual Review of Psychology·J E LeDoux
Jul 1, 1996·Pain·R ZaslanskyD Yarnitsky
Nov 6, 1996·Journal of the Autonomic Nervous System·K DeguchiM Nishioka
Aug 14, 1998·Behaviour Research and Therapy·K Mogg, B P Bradley
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Nov 14, 2000·Trends in Neurosciences·V A Lamme, P R Roelfsema
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
May 21, 2003·Experimental Brain Research·Martin Eimer, Bettina Forster
Aug 29, 2003·Cognitive, Affective & Behavioral Neuroscience·Martin EimerFrancis P McGlone
Feb 1, 1952·Journal of Comparative and Physiological Psychology·J M NOTTERMANP J BERSH
Apr 1, 2004·Cerebral Cortex·Gilles PourtoisPatrik Vuilleumier
Oct 21, 2004·Nature Neuroscience·Patrik VuilleumierRaymond J Dolan
Nov 5, 2004·The European Journal of Neuroscience·Aureliu LavricSimon Forstmeier
Apr 23, 2005·The Journal of Comparative Neurology·Jennifer L Freese, David G Amaral
May 12, 2005·Behaviour Research and Therapy·Shmuel LissekDaniel S Pine
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Aug 11, 2005·Behavioral and Brain Functions : BBF·Urs MaurerBruce D McCandliss
Sep 20, 2005·Brain Research. Cognitive Brain Research·Amanda HolmesMartin Eimer
Jan 13, 2006·Brain Research·Maurizio CodispotiMargaret M Bradley
May 23, 2006·Psychophysiology·Stephan MorattiGregory A Miller
Jun 27, 2006·Neuropsychologia·Romina Palermo, Gillian Rhodes
Oct 4, 2006·Progress in Brain Research·Harald T SchuppMarkus Junghöfer
Oct 10, 2006·Progress in Brain Research·Beatrice de GelderMarco Tamietto
Dec 13, 2006·Molecular Psychiatry·K M Myers, M Davis
Dec 21, 2006·NeuroImage·Christoph ChristmannHerta Flor
Jan 25, 2007·Behavioral and Brain Functions : BBF·Vera C BlauBruce D McCandliss
Mar 27, 2007·Journal of Cognitive Neuroscience·Maurizio CodispotiMargaret M Bradley
Aug 21, 2007·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jaime VilaSonia Rodríguez
Dec 11, 2007·Brain Research·M Carmen PastorPeter J Lang

❮ Previous
Next ❯

Citations

Aug 4, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Maximilian BruchmannThomas Straube

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.